Background: This study aimed to evaluate the effects of standard rescue procedure (SRP) in improving severe trauma treatments in China. Methods: This study was conducted in 12 hospitals located in geographically and industrially different cities in China. A standard procedure on severe trauma rescue was established as a general rule for staff training and patient treatment. A regional network (system) efficiently integrating prehospital rescue, emergency room treatments, and hospital specialist treatments was built under the rule for information sharing and improving severe trauma treatments. Treatment outcomes were compared between before and 1 year after the implementation of the SRP. Results: The outcomes of a total of 74,615 and 12,051 trauma cases were collected from 12 hospitals before and after the implementation of the SRP. Implementation of the SRP led to efficient cooperation and information sharing of different treatment services. The emergency response time, prehospital transit time, emergency rescue time, consultation call time, and mortality rate of patients were 24.24 +/- 4.32 min, 45.69 +/- 3.89 min, 6.38 +/- 1.05 min, 17.53 +/- 0.72 min, and 33.82% +/- 3.87% (n = 441), respectively, before the implementation of the standardization and significantly reduced to 10.11 +/- 3.21 min, 22.39 +/- 4.32 min, 3.26 +/- 0.89 min, 3.45 +/- 0.45 min, and 20.49% +/- 3.11%, separately (n = 495, P < 0.05) after that. Conclusions: Staff training and SRP can significantly improve the efficiency of severe trauma treatments in China.