单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Wuhan 430074, Peoples R China华中科技大学同济医学院附属同济医院[2]Fourth Mil Med Univ, Sch Stomatol, Dept Prosthodont, State Key Lab Mil Stomatol, Xian 710032, Peoples R China[3]Wuhan Univ, Wuhan 430072, Peoples R China[4]Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China[5]Peking Univ, Sch & Hosp Stomatol, Beijing 100871, Peoples R China[6]Georgia Regents Univ, Augusta, GA 30912 USA
Limited continuous replenishment of the mineralization medium is a restriction for in-situ solution-based remineralization of hypomineralized body tissues. Here, we report a process that generated amine-functionalized mesoporous silica nanoparticles for sustained release of biomimetic analogstabilized amorphous calcium phosphate precursors. Both two-dimensional and three-dimensional collagen models can be intrafibrillarly mineralized with these released fluidic intermediate precursors. This represents an important advance in the translation of biomineralization concepts into regimes for in-situ remineralization of bone and teeth.
基金：
NIDCR [R01 DE015306-06]; National High Technology Research and Development Program of China [2015AA020942]; NSFC [81400555]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Wuhan 430074, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Wei,Luo Xiao-juan,Niu Li-na,et al.Biomimetic Intrafibrillar Mineralization of Type I Collagen with Intermediate Precursors-loaded Mesoporous Carriers[J].SCIENTIFIC REPORTS.2015,5:doi:10.1038/srep11199.
APA：
Zhang, Wei,Luo, Xiao-juan,Niu, Li-na,Yang, Hong-ye,Yiu, Cynthia K. Y....&Tay, Franklin R..(2015).Biomimetic Intrafibrillar Mineralization of Type I Collagen with Intermediate Precursors-loaded Mesoporous Carriers.SCIENTIFIC REPORTS,5,
MLA：
Zhang, Wei,et al."Biomimetic Intrafibrillar Mineralization of Type I Collagen with Intermediate Precursors-loaded Mesoporous Carriers".SCIENTIFIC REPORTS 5.(2015)
