Objectives: Coronary heart disease (CHD) has been considered a thromboembolic arterial diseases. The aim of this case-control study was to explore whether the CpG-SNPs of the thrombotic pathway genes contributed to the risk of CHD. Methods and materials: A total of 784 CHD patients and 738 healthy controls were recruited in the current association study, which evaluated 7 CpG-SNPs of the thrombotic pathway genes. The CpG-SNPs included THBS4 rs17878919, CYP2C19 rs12773342, P2RY12 rs1491974, ITGA2 rs26680, FGB rs2227389, F7 rs510317 and F5 rs2269648. SNP genotyping was performed with a Sequenom Mass Spectrometry Genetic Analyzer. Results: Our results demonstrated that CYP2C19 rs12773342 polymorphism was significantly associated with CHD in the recessive model (chi(2) = 5.41, df = 1, P = 0.020, OR = 1.455, 95% CI = 1.060-1.996). A breakdown analysis by age showed that the association of CYP2C19 rs12773342 with CHD was mainly found in individuals aged 55-65 (genotype: chi(2) = 7.93, df = 2, P = 0.019; allele: chi(2) = 4.45, df = 1, P = 0.035). In addition, we also observed a significant association between F7 rs510317 polymorphism and CHD in males (genotype: chi(2) = 7.24, df = 2, P = 0.027). There was no significant association with CHD for the remaining CpG-SNPs. Conclusion: Our results supported that the CYP2C19 rs12773342 and F7 rs510317 polymorphisms were associated with CHD in the Han Chinese population. (C) 2015 Elsevier Masson SAS. All rights reserved.