Leucine-rich repeats and immunoglobulin-like domains (LRIG) 3 gene is mapped to chromosome 12q13.2, a region that is frequently deleted in a subset of glioblastoma multiforme (GBM). It has been reported that perinuclear LRIG3 staining correlated with low WHO grade of glioma and better survival of the patients. However, the relationship between LRIG3 and glioma is not very clear. The purpose of this study is to demonstrate the impacts of LRIG3 on biological characteristics of glioma and its possible mechanisms. We found that transduction of LRIG3 into glioblastoma cells inhibited cell growth in vitro and in vivo, promoted cell apoptosis, and restrained cell invasion and migration. Further studies demonstrated that LRIG3 negatively regulated the epidermal growth factor receptor (EGFR) signaling pathway. Inhibition of EGFR could reduce the effects of LRIG3 knockdown on cell proliferation and EGFR signaling pathway. In conclusion, LRIG3 functions as a tumor suppressor by attenuating EGFR signaling pathway and the restoration of LRIG3 may offer therapeutic potential against malignant gliomas. (C) 2015 Elsevier B.V. All rights reserved.
基金：
Chinese National Nature and Science fund [81001116, 81372711, 81472364]; National Clinical Key Specialty Construction Project of China
通讯机构：[*1]1095 Jiefang Ave, Wuhan 430030, Peoples R China
推荐引用方式(GB/T 7714)：
Guo Dongsheng,Yang Hongkuan,Guo Yang,et al.LRIG3 modulates proliferation, apoptosis and invasion of glioblastoma cells as a potent tumor suppressor[J].JOURNAL OF THE NEUROLOGICAL SCIENCES.2015,350(1-2):61-68.doi:10.1016/j.jns.2015.02.015.
APA：
Guo, Dongsheng,Yang, Hongkuan,Guo, Yang,Xiao, Qungen,Mao, Feng...&Lei, Ting.(2015).LRIG3 modulates proliferation, apoptosis and invasion of glioblastoma cells as a potent tumor suppressor.JOURNAL OF THE NEUROLOGICAL SCIENCES,350,(1-2)
MLA：
Guo, Dongsheng,et al."LRIG3 modulates proliferation, apoptosis and invasion of glioblastoma cells as a potent tumor suppressor".JOURNAL OF THE NEUROLOGICAL SCIENCES 350..1-2(2015):61-68
