Circulating Soluble Neuropilin-1 in Patients with Early Cervical Cancer and Cervical Intraepithelial Neoplasia Can Be Used as a Valuable Diagnostic Biomarker
Objective. To investigate soluble neuropilin-1 (sNRP-1) in circulating and NRP-1 protein in cervical tissues from patients with cervical cancer or cervical intraepithelial neoplasia (CIN). Methods. sNRP-1 was measured in 64 preoperative patients and 20 controls. NRP-1 protein in cervical tissue was detected in 56 patients and 20 controls. Results. Both sNRP-1 and NRP-1 proteins were correlated with stage. sNRP-1 presented a high diagnostic ability of cervical cancer and CIN, with a sensitivity of 70.97% and a specificity of 73.68%. Conclusions. sNRP-1 in circulating can serve as a possible valuable diagnostic biomarker for cervical cancer and CIN.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81202036, 81272860, 81472443]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|4 区医学
小类|3 区病理学4 区生物工程与应用微生物4 区遗传学4 区医学：研究与实验
最新[2025]版：
无
JCR分区：
出版当年[2013]版：
Q2PATHOLOGYQ2MEDICINE, RESEARCH & EXPERIMENTALQ2BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3GENETICS & HEREDITY
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Obstet & Gynecol, Wuhan 430022, Peoples R China[2]Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, New Haven, CT 06520 USA
通讯作者：
推荐引用方式(GB/T 7714)：
Yang Shouhua,Cheng Henghui,Huang Zaiju,et al.Circulating Soluble Neuropilin-1 in Patients with Early Cervical Cancer and Cervical Intraepithelial Neoplasia Can Be Used as a Valuable Diagnostic Biomarker[J].DISEASE MARKERS.2015,2015:doi:10.1155/2015/506428.
APA：
Yang, Shouhua,Cheng, Henghui,Huang, Zaiju,Wang, Xiaoling,Wan, Yinglu...&Wang, Zehua.(2015).Circulating Soluble Neuropilin-1 in Patients with Early Cervical Cancer and Cervical Intraepithelial Neoplasia Can Be Used as a Valuable Diagnostic Biomarker.DISEASE MARKERS,2015,
MLA：
Yang, Shouhua,et al."Circulating Soluble Neuropilin-1 in Patients with Early Cervical Cancer and Cervical Intraepithelial Neoplasia Can Be Used as a Valuable Diagnostic Biomarker".DISEASE MARKERS 2015.(2015)
