Hypoxia-inducible factor 1 alpha (HIF-1 alpha) is closely related to chemoresistance of ovarian cancers. Although it is reported that HIF-1 alpha can be regulated by Sentrin/SUMO-specific protease 1 (SENP1), the effects of SENP1 on HIF-1 alpha is still controversial. In this study, we identified that SENP1 positively regulated the expression of HIF-1 alpha by deSUMOylation and weakened the sensitivity of hypoxic ovarian cancer cells to cisplatin. These results indicate that SENP1 is a positive regulator of HIF-1 alpha and plays a negative role in ovarian cancer chemotherapy.
基金：
Natural Science Foundation of China [NSFC 81101950, 81270105, 81502216]; Clinical Medical Research Project Foundation of Wuhan Municipal Bureau of Health [WX12A10]
第一作者单位：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Inst Pathol,Wuhan 430030,Peoples R China[2]Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Pathol, Wuhan 430030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Ao Qilin,Su Wenjing,Guo Shuang,et al.SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α[J].SCIENTIFIC REPORTS.2015,5:doi:10.1038/srep16396.
APA：
Ao, Qilin,Su, Wenjing,Guo, Shuang,Cai, Lei&Huang, Lei.(2015).SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α.SCIENTIFIC REPORTS,5,
MLA：
Ao, Qilin,et al."SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α".SCIENTIFIC REPORTS 5.(2015)
