Recently, some studies concerning let-7 binding site polymorphism in KRAS 3'-untranslated region (3'UTR) found that rs712 G/T polymorphism increased cancer risk in Chinese population. However, in consistent or contradictory results occurred. Therefore, we performed a comprehensive meta-analysis to clarify this association. Available data from PUBMED, EMBASE, and Chinese National Knowledge In frastructure (CNKI) databases were retrieved up to Feb 1, 2016. 11 studies including 2906 cases and 3544 controls were included in this meta-analysis. Pooled association was presented as odd ratios (ORs) and 95% confidence intervals (CIs) using a fixed-effect model. Significant associations were found between rs712 polymophism and cancer risk in allelic (T vs G, pooled OR = 1.33, 95% CI = 1.22-1.45, P < 0.001), dominant (TT + GT vs GG, pooled OR = 1.29, 95% CI = 1.17-1.44, P < 0.001), recessive (TT vs GT + GG, pooled OR = 2.05, 95% CI = 1.62-2.59, P < 0.001), and additive model (TT vs GG, pooled OR = 2.71, 95% CI = 1.71-2.75, P < 0.001). No publication bias was detected by Begg and Egger tests. In summary, KRAS rs712 polymorphism might confer susceptibility to cancer in Chinese population.