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The recommendations of Chinese Parkinson's disease and movement disorder society consensus on therapeutic management of Parkinson's disease

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单位: [1]Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Neurol, Shanghai 200025, Peoples R China [2]Capital Med Univ, Xuanwu Hosp, Beijing, Peoples R China [3]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan, Peoples R China [4]Beijing Hosp, Beijing, Peoples R China [5]Zhejiang Univ, Sch Med, Hosp 2, Hangzhou, Zhejiang, Peoples R China [6]Dalian Med Univ, Affiliated Hosp 1, Dalian, Peoples R China [7]Soochow Univ, Affiliated Hosp 2, Suzhou, Peoples R China [8]Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China [9]Cent S Univ, Xiangya Hosp, Changsha, Hunan, Peoples R China [10]Guangdong Gen Hosp, Guangzhou, Guangdong, Peoples R China [11]Tianjin Med Univ, Gen Hosp, Tianjin, Peoples R China [12]Sichuan Rehabil Hosp, Chengdu, Peoples R China [13]Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Shanghai, Peoples R China [14]Chinese Peoples Liberat Army Gen Hosp, Beijing, Peoples R China [15]Fujian Med Univ, Union Hosp, Fuzhou, Peoples R China [16]Hebei Med Univ, Affiliated Hosp 1, Shijiazhuang, Peoples R China [17]Peking Union Med Coll Hosp, Beijing, Peoples R China [18]Sichuan Univ, West China Hosp, Chengdu, Peoples R China [19]Shandong Univ, Qilu Hosp, Jinan, Peoples R China [20]Guangzhou Med Univ, Hosp 1, Guangzhou, Guangdong, Peoples R China [21]Fudan Univ, Huashan Hosp, Shanghai, Peoples R China [22]Capital Med Univ, Tiantan Hosp, Beijing, Peoples R China [23]Anhui Med Univ, Hosp 1, Hefei, Peoples R China [24]Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Hangzhou, Zhejiang, Peoples R China [25]Qingdao Univ, Sch Med, Affiliated Hosp, Qingdao, Peoples R China
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关键词: Parkinson's disease Treatment guideline optimal therapeutic options China

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Background: Parkinson's disease (PD) is a chronic, progressive and debilitating disease, which affects over 2.5 million people in China. PD is characterized clinically by resting tremor, muscular rigidity, bradykinesia and postural instability. As the disease progresses, additional complications can arise such as non-motor and neurobehavioral symptoms. Pharmacological treatment and surgical intervention for PD have been implemented in China. Until 10 years ago, there was lack of standardization for the management of PD in different regions and among different physicians, leading to different treatment levels in different regions and different physicians. Since then, the Chinese Parkinson's Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China, in 2006, 2009 and 2014, respectively. Correspondingly, the overall level of treatment for PD in China improved. Objectives: To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence, and to improve the treatment options available to physicians in the management of PD. Summary: A variety of treatment recommendations in the treatment guidelines have been proposed, including physical activity and disease-modifying medication, which should be initiated at the early-stage of the disease. The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs, to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications. Moreover, different treatment strategies should be considered at different stages of the disease. Importantly, treatment guidelines and personalized treatments should be valued equally. A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China.

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大类 | 1 区 医学
小类 | 1 区 神经科学
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第一作者单位: [1]Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Neurol, Shanghai 200025, Peoples R China
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