单位:[1]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Gen Surg,Wuhan 430074,Peoples R China华中科技大学同济医学院附属同济医院[2]Med Coll Wisconsin, Dept Pathol, Milwaukee, WI 53226 USA[3]Med Coll Wisconsin, MCW Canc Ctr, Milwaukee, WI 53226 USA[4]Univ Wisconsin, Joseph J Zilber Sch Publ Hlth, Milwaukee, WI 53201 USA[5]Mayo Clin, Dept Oncol, Div Med Oncol, Rochester, MN USA
Genetic profiling of urine cell free DNA (cfDNA) has not been evaluated in advanced prostate cancer. We performed whole genome sequencing of urine cfDNAs to identify tumor-associated copy number variations in urine before and after initiating androgen deprivation therapy in HSPC stage and docetaxel chemotherapy in CRPC stage. A log2 ratio-based copy number analysis detected common genomic abnormalities in prostate cancer including AR amplification in 5/10 CRPC patients. Other abnormalities identified included TMPRSS2-ERG fusion, PTEN gene deletion, NOTCH1 locus amplification along with genomic amplifications at 8q24.3, 9q34.3, 11p15.5 and 14q11.2, and deletions at 4q35.2, 5q31.3, 7q36.3, 12q24.33, and 16p11.2. By comparing copy number between pre- and post-treatment, we found significant copy number changes in 34 genomic loci. To estimate the somatic tumor DNA fraction in urine cfDNAs, we developed a Urine Genomic Abnormality (UGA) score algorithm that summed the top ten most significant segments with copy number changes. The UGA scores correlated with tumor burden and the change in UGA score after stage-specific therapies reflected disease progression status and overall survival. The study demonstrates the potential clinical utility of urine cfDNAs in predicting treatment response and monitoring disease progression.
基金:
Joseph and Gail Gassner Development funds for prostate cancer research; Advancing a Healthier Wisconsin Fund [5520227]; National Institute of Health [R01CA157881]
第一作者单位:[1]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Gen Surg,Wuhan 430074,Peoples R China[2]Med Coll Wisconsin, Dept Pathol, Milwaukee, WI 53226 USA[3]Med Coll Wisconsin, MCW Canc Ctr, Milwaukee, WI 53226 USA
通讯作者:
推荐引用方式(GB/T 7714):
Xia Yun,Huang Chiang-Ching,Dittmar Rachel,et al.Copy number variations in urine cell free DNA as biomarkers in advanced prostate cancer[J].ONCOTARGET.2016,7(24):35818-35831.doi:10.18632/oncotarget.9027.
APA:
Xia, Yun,Huang, Chiang-Ching,Dittmar, Rachel,Du, Meijun,Wang, Yuan...&Kohli, Manish.(2016).Copy number variations in urine cell free DNA as biomarkers in advanced prostate cancer.ONCOTARGET,7,(24)
MLA:
Xia, Yun,et al."Copy number variations in urine cell free DNA as biomarkers in advanced prostate cancer".ONCOTARGET 7..24(2016):35818-35831