Previous studies had demonstrated that IL-13 and its receptor IL-13R alpha 2 participated in the process of onset and development of colorectal cancer, however, its detailed mechanism was still unclear. Herein, we demonstrated that IL-13 induced the expression of 11 beta HSD2 in an IL-13R alpha 2 dependent manner in colorectal cancer cells. Furthermore, we indicated 11 beta HSD2 was critical for IL-13 to induce the expression of COX2 and activated Akt, which was essential for IL-13 to promote the colony formation abilities and migration abilities of colorectal cancer cells. Inhibitor of 11 beta HSD2 glycyrrhizic acid (GA) significantly reduced the liver metastasis of colorectal cancers cells seeded in the Appendix serous of the nude mice. These results provide evidences to reveal the molecular mechanism in the process of colorectal cancer involving IL-13 and its receptor IL-13R alpha 2, and may provide new therapeutic target for treatment of colorectal cancer.
基金：
NSFC(Natural Science Foundation of China) [81472705]
第一作者单位：[1]Huazhong Univ Sci & Technol,Tongji Med Coll,Affiliated Tongji Hosp,Dept Biliary & Pancreat Surg,Wuhan 430030,Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Jiang Li,Cheng Qi,Zhang Binhao,et al.IL-13 induces the expression of 11βHSD2 in IL-13Rα2 dependent manner and promotes the malignancy of colorectal cancer[J].AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH.2016,8(2):1064-1072.
APA：
Jiang, Li,Cheng, Qi,Zhang, Binhao&Zhang, Mingzhi.(2016).IL-13 induces the expression of 11βHSD2 in IL-13Rα2 dependent manner and promotes the malignancy of colorectal cancer.AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH,8,(2)
MLA：
Jiang, Li,et al."IL-13 induces the expression of 11βHSD2 in IL-13Rα2 dependent manner and promotes the malignancy of colorectal cancer".AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH 8..2(2016):1064-1072
