Esophageal carcinoma is one of the most common malignant tumors and the Kazakh national minority (ethnic) in Xinjiang (northwest of China) has been reported to be one of the highest incidence of Esophageal squamous cell carcinoma (ESCC) in the world. MicroRNA-203 (miR-203) was described as a tumor-suppressive miRNA in several cancers, but little study about the role of miR-203 in Kazakh ESCC. Therefore, we aimed to investigate the role of miR-203 in the occurrence and progression of Kazakh ESCC. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect miR-203 expression, and immunohistochemistry (IHC) was used to examine P63 expression. The expression level of miR-203 in ESCC was significantly lower than that of cancer adjacent normal (CAN) samples (P < 0.05). Whereas the expression level of P63 in ESCC was significantly higher than that of CAN samples (P < 0.05), an inverse association between the expression of P63 and miR-203 was found but was not statistically significant (P > 0.05). These findings suggest that miR-203 is a tumor suppressor gene that plays an important role in inhibiting the occurrence of Kazakh ESCC in Xinjiang, China.
基金：
Ministry of Science and Technology of China [2012AA02A503, 2009BAI82B03, 2010DFB34100]; National Natural Science Foundation [81460363, 81360358, 81560399, 81260301]
第一作者单位：[1]Shihezi Univ, Sch Med, Minist Educ, Dept Pathol, Shihezi 832003, Peoples R China[2]Shihezi Univ, Sch Med, Minist Educ, Key Lab Xinjiang Endem & Ethn Dis, Shihezi 832003, Peoples R China[4]Huazhong Univ Sci & Technol, Tongji Hosp, Dept Oncol, Tongji Med Coll, Wuhan 430030, Peoples R China
通讯作者：
通讯机构：[1]Shihezi Univ, Sch Med, Minist Educ, Dept Pathol, Shihezi 832003, Peoples R China[2]Shihezi Univ, Sch Med, Minist Educ, Key Lab Xinjiang Endem & Ethn Dis, Shihezi 832003, Peoples R China[3]Capital Med Univ, Beijing Chaoyang Hosp, Dept Pathol, Beijing 100020, Peoples R China
推荐引用方式(GB/T 7714)：
Hu Jian Ming,Chang Ai Min,Chen Yun Zhao,et al.Regulatory Role of miR-203 in Occurrence and Progression of Kazakh Esophageal squamous cell carcinoma[J].SCIENTIFIC REPORTS.2016,6:doi:10.1038/srep23780.
APA：
Hu, Jian Ming,Chang, Ai Min,Chen, Yun Zhao,Yuan, Xiang Lin&Li, Feng.(2016).Regulatory Role of miR-203 in Occurrence and Progression of Kazakh Esophageal squamous cell carcinoma.SCIENTIFIC REPORTS,6,
MLA：
Hu, Jian Ming,et al."Regulatory Role of miR-203 in Occurrence and Progression of Kazakh Esophageal squamous cell carcinoma".SCIENTIFIC REPORTS 6.(2016)
