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Association Between the Change in Body Mass Index from Early Adulthood to Midlife and Subsequent Type 2 Diabetes Mellitus

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Pubmed体系：

收录情况： ◇ SCIE

作者：
Sun, Wanwan[1] * ; Shi, Lixin[2] ; Ye, Zhen[3] ; Mu, Yiming[4] ; Liu, Chao[5] ; Zhao, Jiajun[6] ; Chen, Lulu[7] ; Li, Qiang[8] ; Yang, Tao[9] ; Yan, Li[10] ; Wan, Qin[11] ; Wu, Shengli[12] ; Liu, Yan[13] ; Wang, Guixia[13] ; Luo, Zuojie[14] ; Tang, Xulei[15] ; Chen, Gang[16] ; Huo, Yanan[17] ; Gao, Zhengnan[18] ; Su, Qing[19] ; Wang, Youmin[20] ; Qin, Guijun[21] ; Deng, Huacong[22] ; Yu, Xuefeng[23] ; Shen, Feixia[24] ; Chen, Li[25] ; Zhao, Liebin[1] ; Sun, Jichao[1,26,27] ; Ding, Lin[1] ; Xu, Yu[1] ; Xu, Min[1] ; Dai, Meng[1] ; Wang, Tiange[1] ; Zhang, Di[1] ; Lu, Jieli[1] ; Bi, Yufang[1] ; Lai, Shenghan[1,28] ; Li, Donghui[29] ; Wang, Weiqing[1] ; Ning, Guang[1,26,27] ;
单位： [1]Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Natl Clin Res Ctr Metab Dis, Shanghai 200030, Peoples R China [2]Guiyang Med Coll, Affiliated Hosp, Guiyang, Peoples R China [3]Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou, Zhejiang, Peoples R China [4]Chinese Peoples Liberat Army Gen Hosp, Beijing, Peoples R China [5]Jiangsu Prov Hosp Integrat Chinese & Western Med, Nanjing, Jiangsu, Peoples R China [6]Shandong Univ, Shandong Prov Hosp, Jinan 250100, Peoples R China [7]Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Wuhan 430074, Peoples R China [8]Harbin Med Univ, Affiliated Hosp 2, Harbin, Peoples R China [9]Nanjing Med Univ, Jiangsu Prov Hosp, Affiliated Hosp 1, Nanjing, Jiangsu, Peoples R China [10]Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510275, Guangdong, Peoples R China [11]Luzhou Med Coll, Affiliated Hosp, Luzhou, Peoples R China [12]Karamay Municipal Peoples Hosp, Xinjiang, Peoples R China [13]Jilin Univ, Hosp 1, Changchun 130023, Peoples R China [14]Guangxi Med Univ, Affiliated Hosp 1, Nanning, Peoples R China [15]Lanzhou Univ, Hosp 1, Lanzhou 730000, Peoples R China [16]Fujian Med Univ, Fujian Prov Hosp, Fuzhou, Peoples R China [17]Jiangxi Peoples Hosp, Nanchang, Peoples R China [18]Dalian Municipal Cent Hosp, Dalian, Peoples R China [19]Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Shanghai 200030, Peoples R China [20]Anhui Med Univ, Affiliated Hosp 1, Hefei, Peoples R China [21]Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China [22]Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China [23]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430074, Peoples R China [24]Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou, Peoples R China [25]Shandong Univ, Qilu Hosp, Jinan 250100, Peoples R China [26]Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Lab Endocrine & Metab Dis, Shanghai, Peoples R China [27]Shanghai Jiao Tong Univ, Sch Med, Shanghai 200030, Peoples R China [28]Johns Hopkins Univ, Sch Med, Baltimore, MD USA [29]Univ Texas MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Houston, TX 77030 USA
出处：
DOI： 10.1002/oby.21336
ISSN：

摘要：
Objective: To clarify the quantitative relationship of body mass index (BMI) change from early adulthood to midlife with presence of type 2 diabetes mellitus (T2DM) after midlife. Methods: This study included 120,666 middle-aged and elderly, whose retrospectively self-reported body weight at 20 and 40 years and measured height were available. BMI at 20 and 40 years and BMI change in between were defined as early-adulthood BMI, midlife BMI, and early-adulthood BMI change. Results: The odds ratio (OR) for T2DM associated with an 1-unit increment of early-adulthood or midlife BMI was 1.08 (95% confidence interval (CI), 1.07-1.08) and 1.09 (95% CI, 1.09-1.10) respectively. In the cross-tabulation of both early-adulthood BMI and BMI change, the prevalence of T2DM increased across both variables. Compared with participants with normal early-adulthood weight and BMI increase/decrease <= 1, the OR (95% CI) for T2DM of participants with early-adulthood overweight/obesity and BMI increase >= 4 kg/m(2) was 3.49 (3.05-4.00). For participants with early-adulthood underweight and BMI increase/decrease <= 1, the OR (95% CI) was 0.85 (0.75-0.97). Subgroup analysis according to sex and age showed similar trends. Conclusions: Early-adulthood BMI may influence T2DM prevalence after midlife independent of current BMI. T2DM prevalence after midlife was positively associated with early-adulthood weight gain and inversely related to early-adulthood weight loss, while early-adulthood weight loss could not completely negate the adverse effect of early-adulthood overweight/obesity on diabetes.

基金：
China National Clinical Research Center for Metabolic Diseases [2013BAI09B13]; 973 Program [2015CB553600]; National Key New Drug Creation and Manufacturing Program of Ministry of Science and Technology [2012ZX09303006-001]; National Natural Science Foundation of China [81321001, 81390350, 81222008, 81170719, 81130016]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2015]版：
大类 | 2 区 医学
小类 | 2 区 营养学 3 区 内分泌学与代谢
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 内分泌学与代谢 2 区 营养学
JCR分区：
出版当年[2014]版：
Q1 NUTRITION & DIETETICS Q2 ENDOCRINOLOGY & METABOLISM
最新[2023]版：
Q1 ENDOCRINOLOGY & METABOLISM Q1 NUTRITION & DIETETICS

影响因子： 最新[2023版] 最新五年平均 出版当年[2014版] 出版当年五年平均 出版前一年[2013版] 出版后一年[2015版]

第一作者：
第一作者单位： [1]Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Natl Clin Res Ctr Metab Dis, Shanghai 200030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Sun Wanwan,Shi Lixin,Ye Zhen,et al.Association Between the Change in Body Mass Index from Early Adulthood to Midlife and Subsequent Type 2 Diabetes Mellitus[J].OBESITY.2016,24(3):703-709.doi:10.1002/oby.21336.
APA：
Sun, Wanwan,Shi, Lixin,Ye, Zhen,Mu, Yiming,Liu, Chao...&Ning, Guang.(2016).Association Between the Change in Body Mass Index from Early Adulthood to Midlife and Subsequent Type 2 Diabetes Mellitus.OBESITY,24,(3)
MLA：
Sun, Wanwan,et al."Association Between the Change in Body Mass Index from Early Adulthood to Midlife and Subsequent Type 2 Diabetes Mellitus".OBESITY 24..3(2016):703-709

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