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Association of autophagy-related IRGM polymorphisms with latent versus active tuberculosis infection in a Chinese population

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收录情况： ◇ SCIE

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单位： [1]Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China [2]Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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关键词： IRGM Tuberculosis Polymorphism Autophagy Infection

摘要：

The autophagy-related immunity-related GTPase family M protein, IRGM, plays an important role in the defense against tuberculosis (TB) infection. IRGM polymorphisms are associated with TB infection susceptibility, and recent studies demonstrate host genetic differences between active and latent TB. Here, we investigated the association between IRGM polymorphisms and TB infection type in a Chinese population. We recruited 268 and 321 patients with confirmed or latent TB, respectively, and 475 TB-free healthy controls. Three single nucleotide polymorphisms, rs10065172, rs10051924, and rs13361189 within IRGM were genotyped using TaqMan-based assays. Interferon-gamma release levels were tested by T-SPOT. rs10065172 (P = 0.024, OR 0.67 (95% CI 0.48-0.95)), rs10051924 (P = 0.01, OR 0.64 (95% CI 0.46-0.90)), and rs13361189 (P = 0.055, OR 0.72 (95% CI 0.51-1.01)) were associated with a protective role against latent TB progression. Haplotype analysis showed that TCC was protective for latent TB (P = 0.022, OR 0.74 (95% CI 0.57-0.96)) whereas TTC conferred a higher risk of active TB. Additionally, patients with the rs10065172 TT genotype had a higher response to TB specific antigens. Thus, IRGM polymorphism differences between latent and active TB suggests that genetic differences in autophagy might partly affect host TB infection status. (c) 2016 Elsevier Ltd. All rights reserved.

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出版当年[2015]版：

大类 | 3 区医学

小类 | 3 区免疫学 3 区微生物学 3 区呼吸系统

最新[2025]版：

大类 | 4 区医学

小类 | 4 区免疫学 4 区微生物学 4 区呼吸系统

JCR分区：

出版当年[2014]版：

Q2 MICROBIOLOGY Q2 RESPIRATORY SYSTEM Q3 IMMUNOLOGY

最新[2023]版：

Q2 RESPIRATORY SYSTEM Q3 IMMUNOLOGY Q3 MICROBIOLOGY

影响因子： 2.8 最新[2023版] 2.6 最新五年平均 2.711 出版当年[2014版] 3.085 出版当年五年平均 3.503 出版前一年[2013版] 2.952 出版后一年[2015版]

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第一作者单位： [1]Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

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