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Autophagy protects podocytes from sublytic complement induced injury

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收录情况： ◇ SCIE

作者：

单位： [1]Department of Pediatrics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [2]Department of Anesthesiology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [3]Department of Pediatrics,Tongji Hospital,Tongji Medical College, Huazhong University of Science and Technology,No.1095,Jiefang Ave., Wuhan 30030,P.R.China.

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关键词： Autophagy Podocyte Sublytic C5b-9 Complement

摘要：

Podocyte injury induced by sublytic complement attack is the main feature of membranous nephropathy (MN). This study aimed at investigating the impact of sublytic complement attack-related autophagy on podocyte injury in vitro. Here, we show that sublytic complement attack enhances MPC5 podocyte autophagy in vitro. Inhibition of autophagy by treatment with 3-methyladenine (3-MA) significantly increased sublytic complement attack-induced changes in the injury-related morphology, stress fiber, and podocyte apoptosis, but decreased the survival and adhesion of MPC5 podocytes. In contrast, promotion of autophagy by treatment with rapamycin mitigated sublytic complement attack-induced changes in the injury-related morphology, stress fiber, and podocyte apoptosis, but increased the survival and adhesion of MPC5 podocytes. These data suggest that autophagy may protect podocytes from sublytic complement attack-induced injury in vitro. (C) 2016 Elsevier Inc. All rights reserved.

基金：

基金编号： 81100514

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中科院(CAS)分区：

出版当年[2015]版：

大类 | 3 区医学

小类 | 3 区肿瘤学 4 区细胞生物学

最新[2025]版：

大类 | 3 区生物学

小类 | 4 区细胞生物学 4 区肿瘤学

JCR分区：

出版当年[2014]版：

Q2 ONCOLOGY Q3 CELL BIOLOGY

最新[2023]版：

Q2 ONCOLOGY Q3 CELL BIOLOGY

影响因子： 3.3 最新[2023版] 3.3 最新五年平均 3.246 出版当年[2014版] 3.377 出版当年五年平均 3.372 出版前一年[2013版] 3.378 出版后一年[2015版]

第一作者：

第一作者单位： [1]Department of Pediatrics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

通讯作者：

通讯机构： [3]Department of Pediatrics,Tongji Hospital,Tongji Medical College, Huazhong University of Science and Technology,No.1095,Jiefang Ave., Wuhan 30030,P.R.China.

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