BackgroundSevere burn injury has been demonstrated to delay gastric emptying. The aim of this study was to investigate effects and cellular mechanisms of auricular electroacupuncture (AEA) at the acupoints innervated by the auricular branch of vagus nerve on burn-induced gastric dysmotility in rats. MethodsPropranolol (-adrenoceptor antagonist) was injected intraperitoneally after the rats underwent burn injury. All experiments were performed 6 h following burn/sham burn injury. AEA was performed at bilateral auricular acupoints for 45 min. Electrocardiogram was recorded for 30 min. Plasma hormones were measured; cyclooxygenase (COX)-2 expressions in gastric tissue were measured using western blotting and real-time RT-PCR. Key Results(i) Burn injury delayed gastric emptying (p = 0.006) and AEA increased gastric emptying by 49% (p = 0.045). (ii) Burn injury evoked a significant elevation in plasma noradrenaline, which was suppressed by AEA. (iii) Burn injury significantly increased protein and mRNA expressions of COX-2 in gastric fundus and antrum. AEA suppressed burn-induced increase in protein expressions, but not mRNA expressions of COX-2. Conclusions & InferencesBurn injury delays gastric emptying by up-regulating COX-2 attributed to sympathetic overactivity. AEA improves burn-induced delay in gastric emptying, possibly mediated via the sympathetic-COX-2 pathway.
第一作者单位：[1]Univ Texas Med Branch, Dept Internal Med, Div Gastroenterol, Galveston, TX 77555 USA[2]Huazhong Univ Sci & Technol, Dept Pediat, Tongji Hosp, Tongji Med Coll, Wuhan 430074, Peoples R China
通讯作者：
通讯机构：[1]Univ Texas Med Branch, Dept Internal Med, Div Gastroenterol, Galveston, TX 77555 USA[3]Johns Hopkins Sch Med, Div Gastroenterol & Hepatol, Baltimore, MD 21224 USA[*1]Johns Hopkins Sch Med, Div Gastroenterol & Hepatol, 4940 Eastern Ave,A-505, Baltimore, MD 21224 USA
推荐引用方式(GB/T 7714)：
Li H.,Yin J.,Zhang Z.,et al.Auricular vagal nerve stimulation ameliorates burn-induced gastric dysmotility via sympathetic-COX-2 pathways in rats[J].NEUROGASTROENTEROLOGY AND MOTILITY.2016,28(1):36-42.doi:10.1111/nmo.12693.
APA：
Li, H.,Yin, J.,Zhang, Z.,Winston, J. H.,Shi, X. -Z.&Chen, J. D. Z..(2016).Auricular vagal nerve stimulation ameliorates burn-induced gastric dysmotility via sympathetic-COX-2 pathways in rats.NEUROGASTROENTEROLOGY AND MOTILITY,28,(1)
MLA：
Li, H.,et al."Auricular vagal nerve stimulation ameliorates burn-induced gastric dysmotility via sympathetic-COX-2 pathways in rats".NEUROGASTROENTEROLOGY AND MOTILITY 28..1(2016):36-42
