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Clinical significance of circulating tumor cells in patients with small-cell lung cancer

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收录情况： ◇ SCIE

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单位： [1]Huazhong Univ Sci & Technol, Tongji Med Sch, Tongji Hosp, Dept Oncol, Wuhan, Peoples R China [2]Peoples Hosp Xinjiang Uygyr Autonomous Reg, Dept Radiat Oncol, Uygyr, Peoples R China [3]Shihezi Univ, Sch Med, Affiliated Hosp 1, Dept Oncol, 107 North Two Rd, Shihezi 832008, Peoples R China

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关键词： Circulating tumor cells Clinical characteristics Prognosis Progression-free survival Small-cell lung cancer

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Background: This study investigated the correlation of the presence of circulating tumor cells (CTCs) with clinical characteristics, and the predictive value of CTCs for progression-free survival (PFS) in patients with small-cell lung cancer (SCLC). Methods: Samples were obtained from 42 patients with SCLC before and after the first cycle of chemotherapy. CTCs were quantitated by negative immunomagnetic enrichment and immunocytochemistry using anti-CD45 and anti-pancytokeratin antibodies. Results: CTCs were positive (>= 2) in 76.19% of patients with SCLC and negative in the control group. The presence of CTCs was positively correlated with 6 clinical characteristics. PFS was 6.055 and 10.670 months for patients with >= 2 and <2 CTCs/7.5 mL of blood before chemotherapy; after chemotherapy PFS was 4.862 and 10.535 months, respectively. Conclusions: This study showed that both baseline CTC numbers and the change in CTC numbers after 1 cycle of chemotherapy are significant prognostic factors of PFS for SCLC.

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出版当年[2016]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

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出版当年[2015]版：

Q4 ONCOLOGY

最新[2023]版：

Q3 ONCOLOGY

影响因子： 2.4 最新[2023版] 1.9 最新五年平均 1.071 出版当年[2015版] 1.218 出版当年五年平均 1.269 出版前一年[2014版] 1.233 出版后一年[2016版]

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第一作者单位： [1]Huazhong Univ Sci & Technol, Tongji Med Sch, Tongji Hosp, Dept Oncol, Wuhan, Peoples R China

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