Two new functionalized ergostane-type steroids, phomopsterones A (1) and B (2), were isolated from the plant-derived Phomopsis sp. TJ507A. Their structures were determined on the basis of spectroscopic data, a modified Mosher's method, X-ray crystallographic analysis, and quantum chemical calculations. Compound 1 is an unprecedented ergosteroid featuring a, rearranged bicyclo[3.3.1]nonane motif resulting from B-ring scission and a subsequent 180 degrees rotation of the ring A during biosynthesis. Compound 2 exhibited anti-inflammatory activity.
基金：
Program for New Century Excellent Talents in University, State Education Ministry of China [NCET-2008-0224]; National Natural Science Foundation of China [31200258, 31370372, 31270395, 81573316, 81641129]; National Science and Technology Project of China [2011ZX09102-004]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Sch Pharm, Wuhan 430030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Hu Zhengxi,Wu Ye,Xie Shuangshuang,et al.Phomopsterones A and B, Two Functionalized Ergostane-Type Steroids from the Endophytic Fungus Phomopsis sp TJ507A[J].ORGANIC LETTERS.2017,19(1):258-261.doi:10.1021/acs.orglett.6b03557.
APA：
Hu, Zhengxi,Wu, Ye,Xie, Shuangshuang,Sun, Weiguaug,Guo, Yi...&Zhang, Yonghui.(2017).Phomopsterones A and B, Two Functionalized Ergostane-Type Steroids from the Endophytic Fungus Phomopsis sp TJ507A.ORGANIC LETTERS,19,(1)
MLA：
Hu, Zhengxi,et al."Phomopsterones A and B, Two Functionalized Ergostane-Type Steroids from the Endophytic Fungus Phomopsis sp TJ507A".ORGANIC LETTERS 19..1(2017):258-261
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