Tumor necrosis factor alpha (TNF-alpha), originally described as an anti-neoplastic cytokine, has been found, in apparent contradiction to its name, to play an important role in promoting the development and progression of malignant disease. Targeting TNF-alpha with TNF antagonists has elicited an objective response in certain solid tumors in phase I and II clinical trials. This review focuses on the relationship of TNF-alpha expressed by leukemia cells and adverse clinical features of leukemia. TNF-alpha is involved in all steps of leukemogenesis, including cellular transformation, proliferation, angiogenesis, and extramedullary infiltration. TNF-alpha is also an important factor in the tumor microenvironment and assists leukemia cells in immune evasion, survival, and resistance to chemotherapy. TNF-alpha may be a potent target for leukemia therapy. Copyright 2016 ISEH - International Society for Experimental Hematology. Published by Elsevier Inc.
基金：
National Science Foundation for Young Scholars of China [81300415]; Key Program of National Natural Science Foundation of China [81230052]
第一作者单位：[1]Tongji Hosp, Dept Hematol, Wuhan, Hubei, Peoples R China
通讯作者：
通讯机构：[1]Tongji Hosp, Dept Hematol, Wuhan, Hubei, Peoples R China[*1]1095 Jiefang Ave, Wuhan Shi 430000, Hubei Sheng, Peoples R China
推荐引用方式(GB/T 7714)：
Zhou Xiaoxi,Li Zhuoya,Zhou Jianfeng.Tumor necrosis factor a in the onset and progression of leukemia[J].EXPERIMENTAL HEMATOLOGY.2017,45:17-26.doi:10.1016/j.exphem.2016.10.005.
APA：
Zhou, Xiaoxi,Li, Zhuoya&Zhou, Jianfeng.(2017).Tumor necrosis factor a in the onset and progression of leukemia.EXPERIMENTAL HEMATOLOGY,45,
MLA：
Zhou, Xiaoxi,et al."Tumor necrosis factor a in the onset and progression of leukemia".EXPERIMENTAL HEMATOLOGY 45.(2017):17-26
