Tumor environment plays a pivotal role in determining cancer biology characteristics. Cytokine factors, as a critical component in tumor milieu, execute distinct functions in the process of tumorigenesis and progression via the autocrine or paracrine manner. The retinal determination gene network (RDGN), which mainly comprised DACH, SIX, and EYA family members, is required for the organ development in mammalian species. While the aberrant expression of RDGN is involved in the proliferation, apoptosis, angiogenesis, and metastasis of tumors via interacting with different cytokine-related signals, such as CXCL8, IL-6, TGF-beta, FGF, and VEGF, in a cell-or tissue-dependent manner. Thus, joint detection of this pathway might be used as a potential biomarker for the stratification of target therapy and for the precision prediction of the prognosis of cancer patients.
基金：
National Natural Science Foundation of China [81572608, 81874120, 81172422]; Wuhan Science and Technology Bureau [2017060201010170]
第一作者单位：[1]Pingdingshan Univ, Sch Med, Dept Clin Med, Pingdingshan 467000, Henan, Peoples R China[2]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Oncol, 1095 Jie Fang Ave, Wuhan 430030, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Zheng Xinhua,Liu Qian,Yi Ming,et al.The regulation of cytokine signaling by retinal determination gene network pathway in cancer[J].ONCOTARGETS AND THERAPY.2018,11:6479-6487.doi:10.2147/OTT.S176113.
APA：
Zheng, Xinhua,Liu, Qian,Yi, Ming,Qin, Shuang&Wu, Kongming.(2018).The regulation of cytokine signaling by retinal determination gene network pathway in cancer.ONCOTARGETS AND THERAPY,11,
MLA：
Zheng, Xinhua,et al."The regulation of cytokine signaling by retinal determination gene network pathway in cancer".ONCOTARGETS AND THERAPY 11.(2018):6479-6487
