Small molecule-protein interactions in branch migration thermodynamics: modelling and application in the homogeneous detection of proteins and small molecules
We have disclosed the unique inhibition effect of small molecule-protein interactions toward the DNA branch migration process and constructed a complete thermodynamic model for it. The disclosed effect was further coupled with the steric hindrance effect to establish a homogeneous assay for proteins and small molecules with ultra-high inhibition factors and sensitivity.
基金：
Natural Science Foundation of Hubei Province [2017CFB117]; Hubei Province Health and Family Planning Scientific Research Project [J2017Q017]; Wuhan Youth Science and Technology Plan [2017050304010293]; National Science Foundation of China [21705053]
第一作者单位：[1]Huazhong Univ Sci & Technol, Ctr Reprod Med, Family Planning Res Inst, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China[2]Huazhong Univ Sci & Technol, Union Hosp, Dept Obstet & Gynaecol, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhou Xing,Cui Zhangbo,Liu Liquan,et al.Small molecule-protein interactions in branch migration thermodynamics: modelling and application in the homogeneous detection of proteins and small molecules[J].ANALYST.2018,143(12):2755-2759.doi:10.1039/c8an00555a.
APA：
Zhou, Xing,Cui, Zhangbo,Liu, Liquan,Sun, Ziyong,Lin, Meng...&Xiao, Xianjin.(2018).Small molecule-protein interactions in branch migration thermodynamics: modelling and application in the homogeneous detection of proteins and small molecules.ANALYST,143,(12)
MLA：
Zhou, Xing,et al."Small molecule-protein interactions in branch migration thermodynamics: modelling and application in the homogeneous detection of proteins and small molecules".ANALYST 143..12(2018):2755-2759
