In the present study, whole genome mRNA expression profiles in cardiac ischemia regions of rats with cardiac ischemia/reperfusion injury were analyzed to identify unique target genes. A total of 544 differentially expressed genes were identified between normal and cardiac ischemia samples. Our results identified ten key genes CXCR1, GLP1R, CCL21, GRK1, oxidative stress induced growth inhibitor 1 (OSGIN1), iroquois homeobox 1 (IRX1), opioid binding protein/cell adhesion molecule-like (OPCML), gi vertical bar 672075288 vertical bar ref vertical bar XR_595614.1 vertical bar, NON-RATT008949, XR_601753.1, NONRATT008080 were related to cardiac ischemia/reperfusion injury. These candidate genes were further examined in a cardiac ischemia/reperfusion model so as to provide important therapeutic targets for the treatment of local cardiac injury.
基金：
National Natural Science Foundation of P.R. China [81670240, 81770283]; National Natural Science Foundation of Hubei Province [2016CFB625]; Medical innovation project in Fujian Province [2017-CX-48]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Anesthesiol & Pain Med, Tongji Hosp, Wuhan 430030, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Quan,He Zhi-Gang,Li Zhi-Xiao,et al.Bioinformatics analysis of gene expression profile data to screen key genes involved in cardiac ischemia-reperfusion injury[J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE.2018,11(5):4955-4966.
APA：
Wang, Quan,He, Zhi-Gang,Li, Zhi-Xiao,Li, Shun-Yuan,Chen, Ying-Le...&Xiang, Hong-Bing.(2018).Bioinformatics analysis of gene expression profile data to screen key genes involved in cardiac ischemia-reperfusion injury.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,11,(5)
MLA：
Wang, Quan,et al."Bioinformatics analysis of gene expression profile data to screen key genes involved in cardiac ischemia-reperfusion injury".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 11..5(2018):4955-4966
