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Association of angiotensin receptor 2 gene polymorphisms with pregnancy induced hypertension risk

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单位: [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan, Hubei, Peoples R China [2]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Hosp Infect Management,Wuhan,Hubei,Peoples R China [3]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Neurol,Wuhan,Hubei,Peoples R China
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关键词: Angiotensin receptor 2 pregnancy induced hypertension single nucleotide polymorphisms haplotype analysis

摘要:
Objectives: To investigate the association of polymorphisms and haplotypes of angiotensin receptor 2 (AT2R) gene with pregnancy induced hypertension (PIH) in Chinese Han women. Methods: A case-control study was designed with 446 cases (gestational hypertension, GH: 124; pre-eclampsia, PE + eclampsia, E: 322) and 650 controls. rs5193, rs1403543 and rs12710567 of AT2R gene were genotyped. A logistic regression approach was applied to estimate the relationship between the polymorphisms and haplotypes of AT2Rgene with PIH risk. Results: No relationship between AT2R gene polymorphisms and PIH was detected. The haplotype analysis also showed a negative result. Conclusions: rs5193, rs1403543 and rs12710567 of AT2R gene might have no effect on PIH risk among Chinese Han women.

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出版当年[2017]版:
大类 | 4 区 医学
小类 | 4 区 妇产科学 4 区 外周血管病 4 区 生理学
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 妇产科学 4 区 外周血管病 4 区 生理学
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出版当年[2016]版:
Q4 PHYSIOLOGY Q4 PERIPHERAL VASCULAR DISEASE Q4 OBSTETRICS & GYNECOLOGY
最新[2023]版:
Q3 OBSTETRICS & GYNECOLOGY Q3 PERIPHERAL VASCULAR DISEASE Q4 PHYSIOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

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第一作者单位: [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan, Hubei, Peoples R China
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