Objectives: To investigate the association of polymorphisms and haplotypes of angiotensin receptor 2 (AT2R) gene with pregnancy induced hypertension (PIH) in Chinese Han women. Methods: A case-control study was designed with 446 cases (gestational hypertension, GH: 124; pre-eclampsia, PE + eclampsia, E: 322) and 650 controls. rs5193, rs1403543 and rs12710567 of AT2R gene were genotyped. A logistic regression approach was applied to estimate the relationship between the polymorphisms and haplotypes of AT2Rgene with PIH risk. Results: No relationship between AT2R gene polymorphisms and PIH was detected. The haplotype analysis also showed a negative result. Conclusions: rs5193, rs1403543 and rs12710567 of AT2R gene might have no effect on PIH risk among Chinese Han women.
基金:
National Natural Science Foundation of China [81172679/H2605]
第一作者单位:[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan, Hubei, Peoples R China
通讯作者:
推荐引用方式(GB/T 7714):
Li Chenyang,Peng Weijun,Zhang Heng,et al.Association of angiotensin receptor 2 gene polymorphisms with pregnancy induced hypertension risk[J].HYPERTENSION IN PREGNANCY.2018,37(2):87-92.doi:10.1080/10641955.2018.1460666.
APA:
Li, Chenyang,Peng, Weijun,Zhang, Heng&Yan, Weirong.(2018).Association of angiotensin receptor 2 gene polymorphisms with pregnancy induced hypertension risk.HYPERTENSION IN PREGNANCY,37,(2)
MLA:
Li, Chenyang,et al."Association of angiotensin receptor 2 gene polymorphisms with pregnancy induced hypertension risk".HYPERTENSION IN PREGNANCY 37..2(2018):87-92