This meta-analysis aimed to compare the diagnostic performance of contrast-enhanced ultrasound (CEUS), conventional ultrasound (US) combined with CEUS (US + CEUS) and US for distinguishing breast lesions. From thorough literature research, studies that compared the diagnostic performance of CEUS versus US or US + CEUS versus US, using pathology results as the gold standard, were included. Atotal of 10 studies were included, of which 9 compared the diagnostic performance of CEUS and US, and 5 studies compared US + CEUS and US. In those comparing CEUS versus US, the pooled sensitivity was 0.93 (95% CI: 0.91-0.95) versus 0.87 (95% CI: 0.85-0.90) and pooled specificity was 0.86 (95% CI: 0.84-0.88) versus 0.72 (95% CI: 0.69-0.75). In studies comparing US + CEUS versus US, the pooled sensitivity was 0.94 (95% CI: 0.92-0.96) versus 0.87 (95% CI: 0.84-0.90) and pooled specificity was 0.86 (95% CI: 0.82-0.89) versus 0.80 (95% CI: 0.76-0.84). In terms of diagnosing breast malignancy, areas under the curve of the summary receiver operating characteristic (of both CEUS (p = 0.003) and US + CEUS (p = 0.000) were statistically higher than that of US. Both CEUS alone and US + CEUS had better diagnostic performance than US in differentiation of breast lesions, and US + CEUS also had low negative likelihood ratio. (E-mail: xiangfx@hotmail.com) (c) 2018World Federation for Ultrasound in Medicine & Biology. All rights reserved.
基金：
Fundamental Research Funds for the Central Universities in China [2017 KFYXJJ255]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|3 区医学
小类|2 区声学3 区核医学
最新[2025]版：
大类|3 区医学
小类|3 区声学3 区核医学
JCR分区：
出版当年[2016]版：
Q1ACOUSTICSQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q2ACOUSTICSQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者单位：[1]Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Boston, MA USA
通讯作者：
通讯机构：[7]Huazhong Univ Sci & Technol, Union Hosp, Dept Ultrasound, Tongji Med Coll, 1277 JieFang Ave, Wuhan 430022, Hubei, Peoples R China[8]Huazhong Univ Sci & Technol, Union Hosp, Dept Ultrasound, Tongji Med Coll,Hubei Prov Key Lab Mol Imaging, 1277 JieFang Ave, Wuhan 430022, Hubei, Peoples R China
推荐引用方式(GB/T 7714)：
Li Qian,Hu Min,Chen Zhikui,et al.META-ANALYSIS: CONTRAST-ENHANCED ULTRASOUND VERSUS CONVENTIONAL ULTRASOUND FOR DIFFERENTIATION OF BENIGN AND MALIGNANT BREAST LESIONS[J].ULTRASOUND IN MEDICINE AND BIOLOGY.2018,44(5):919-929.doi:10.1016/j.ultrasmedbio.2018.01.022.
APA：
Li, Qian,Hu, Min,Chen, Zhikui,Li, Changtian,Zhang, Xi...&Xiang, Feixiang.(2018).META-ANALYSIS: CONTRAST-ENHANCED ULTRASOUND VERSUS CONVENTIONAL ULTRASOUND FOR DIFFERENTIATION OF BENIGN AND MALIGNANT BREAST LESIONS.ULTRASOUND IN MEDICINE AND BIOLOGY,44,(5)
MLA：
Li, Qian,et al."META-ANALYSIS: CONTRAST-ENHANCED ULTRASOUND VERSUS CONVENTIONAL ULTRASOUND FOR DIFFERENTIATION OF BENIGN AND MALIGNANT BREAST LESIONS".ULTRASOUND IN MEDICINE AND BIOLOGY 44..5(2018):919-929
