PurposeTo measure changes in anterior chamber structure before and after exercise in healthy individuals using anterior segment optical coherence tomography (ASOCT). MethodsThirty-two healthy young individuals performed jogging for 20min. Eye blinking rate was recorded during rest and exercise. The anterior chamber angle (ACA), angle opening distance at 500m from the scleral spur (AOD500), trabecular-iris space area at 500m from the scleral spur (TISA500), iris concavity (IC), iris concavity ratio (CR), iris thickness at 750m from the scleral spur (IT750), anterior chamber depth (ACD), anterior chamber width (ACW), pupil diameter (PD), intraocular pressure (IOP), blood pressure (BP) and heart rate (HR) were recorded before and after exercise. Anterior chamber angle (ACA), AOD500, TISA500, IC, IT750, ACD, ACW and PD were measured with ASOCT. ResultsCompared with rest, the blinking rate during exercise did not change significantly (13.045.80 versus 13.52 +/- 5.87 blinks/min, p=0.645). The average IOP (15.4 +/- 2.4 versus 12.4 +/- 2.1mmHg), ACA (35.96 +/- 11.35 versus 40.25 +/- 12.64 degrees), AOD500 (0.800 +/- 0.348 versus 0.942 +/- 0.387mm), TISA500 (0.308 +/- 0.155 versus 0.374 +/- 0.193mm(2)), IC (-0.078 +/- 0.148 versus -0.153 +/- 0.159mm) and CR (-0.027 +/- 0.050 versus -0.054 +/- 0.056) changed significantly (all p<0.001), while the average IT750 (0.463 +/- 0.084 versus 0.465 +/- 0.086mm; p=0.492), ACD (3.171 +/- 0.229 versus 3.175 +/- 0.238mm; p=0.543) and ACW (11.768 +/- 0.377 versus 11.755 +/- 0.378mm; p=0.122) showed no significant change after exercise. ConclusionThe blinking rate did not change significantly during exercise, while ACA, AOD500 and TISA500 increased after exercise. Exercise also induced or increased IC. These changes in anterior chamber structure were only associated with exercise, but not with the postexercise change in PD or IOP.