Objective: To explore the effects of multimodal pain management on pain degree, sleep quality and psychological states of patients with long bone fracture. Methods: Ninety-eight patients with long bone fracture who were treated by internal fixation were enrolled and, according to random number table, divided into a control group (n = 49) receiving routine nursing and an experimental group (n = 49) receiving multimodal pain management based on routine nursing. The two groups of patients were compared in terms of pain degree, sleep quality, psychological states, coping styles, the number of postoperative patient-controlled analgesia (PCA) uses and nursing satisfaction. Results: At 1 and 3 days after operation, the Numerical RatingScale (NRS) scores of resting and active states in the experimental group were significantly lower than those in the control group (all P = 0.000). At 4 weeks after intervention, the Pittsburgh Sleep Quality Index (PSQI), the Self-Rating Scale of Sleep (SRSS), the Self-Rating Anxiety Scale (SAS) and the Self-Rating Depression Scale (SDS) scores in the experimental group were significantly lower than those in the control group (all P = 0.000). Compared with the control group, patients in the experimental group had a significantly higher positive coping score (P = 0.000), but a significantly lower negative coping score (P = 0.000). The number of PCA uses within postoperative 6, 24 and 48 hours were lower in the experimental than those in the control group (P = 0.002, P = 0.000 and P = 0.000 respectively). Pain education, perception of pain control and overall nursing satisfaction in the experimental group were significantly higher than those in the control group (P = 0.025, P = 0.029 and P = 0.004 respectively). Conclusion: Multimodal pain management for patients with long bone fracture is conducive to pain relief, sleep quality improvement, negative emotion regulation, relationship improvement between patients and nurses, promoting patients' positive response to disease and reduced number of postoperative PCA uses.