OBJECTIVE: To explore the correlations of endothelial nitric oxide synthase (eNOS) G894T and endothelin-2 (ET-2) A985G gene polymorphisms with eclampsia. PATIENTS AND METHODS: A total of 110 eclampsia patients in our hospital from July 2014 to August 2017 were enrolled as the observation group and 100 healthy pregnant women in the same period as the control group. The polymorphisms of eNOS G894T and ET-2 A985G genes in the two groups were analyzed via polymerase chain reaction (PCR), and their correlations with eclampsia risk were investigated. RESULTS: The distribution frequency of eNOS G894T genotype TT and GT and T allele, as well as the ET-2 A985G genotype GG and AG and G allele, were evidently higher in the observation group than in the control group (p<0.05). ENOS G894T genotype TT and ET-2 A985G genotype GG were significantly associated with the occurrence of eclampsia. CONCLUSIONS: The polymorphisms of eNOS G894T and ET-2 A985G genes are correlated with the occurrence of eclampsia.
基金：
National Natural Science Foundation of China [81701476]; Hubei Provincial Natural Science Foundation of China [2016CFB321]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Obstet & Gynecol, Wuhan, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Yu N.,Fan L.,Wu J-L,et al.Analysis on the correlations of ENOS and ET-2 gene polymorphisms with eclampsia[J].EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES.2019,23(16):6800-6805.doi:10.26355/eurrev_201908_18718.
APA：
Yu, N.,Fan, L.,Wu, J-L,Chen, S-H&Li, W..(2019).Analysis on the correlations of ENOS and ET-2 gene polymorphisms with eclampsia.EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES,23,(16)
MLA：
Yu, N.,et al."Analysis on the correlations of ENOS and ET-2 gene polymorphisms with eclampsia".EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES 23..16(2019):6800-6805
