The current study is aimed to explore the specific genes which are responsible for the manifestation of Immunoglobulin A nephropathy (IgAN). Gene expression profiles GSE37460, GSE93798 and GSE104948 were analyzed using biological informatics methods to identify differentially expressed genes (DEGs) in IgAN glomeruli samples which were then compared to normal control samples. Subsequently, the DEGs were overlapped to explore genes with significant expression in at least two profiles. Finally, the enrichment analysis was conducted and the protein-protein interaction (PPI) network was constructed for the overlapping DEGs. A total of 28 genes were up-regulated and 10 genes were down-regulated. The up-regulated genes including CD44 and FN1 were chiefly involved in extracellular matrix receptors interaction pathway. In addition, CX3CR1 and CCL4 were associated with chemokine signaling pathway. ITGB2, PTPRC, FN1, and FCER1G were hub genes with a high degree of interaction in the PPI network. Therefore, this study identified many significant genes associated with extracellular matrix expansion and inflammatory mechanism which may be the novel biomarker and target candidates in IgAN.
基金：
Major Research plan of the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [91742204]; international (regional) cooperation and exchange projects, (NSFC-DFG) [81761138041]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81470948, 81670633, 81570667]; National Key Research and Development Program [2016YFC0906103]; National Key Technology RD ProgramNational Key Technology R&D Program [2013BAI09B06, 2015BAI12B07]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Nephrol, Wuhan, Hubei, Peoples R China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Miraji Mohammed Khamis,Cheng Yichun,Ge Shuwang,et al.Identification of primary genes in glomeruli compartment of immunoglobulin A nephropathy by bioinformatic analysis[J].PEERJ.2019,7:doi:10.7717/peerj.7067.
APA：
Miraji, Mohammed Khamis,Cheng,Yichun,Ge, Shuwang&Xu,Gang.(2019).Identification of primary genes in glomeruli compartment of immunoglobulin A nephropathy by bioinformatic analysis.PEERJ,7,
MLA：
Miraji, Mohammed Khamis,et al."Identification of primary genes in glomeruli compartment of immunoglobulin A nephropathy by bioinformatic analysis".PEERJ 7.(2019)
