Discontinuation of tyrosine kinase inhibitor (TKI) therapy after achieving a persistent deep molecular response (DMR) is an urgently needed treatment goal for chronic myeloid leukemia (CML) patients and has been included in the National Comprehensive Cancer Network (NCCN) guidelines (version 2.2017) for CML. Indeed, various studies have confirmed the feasibility of discontinuing TKI therapy. In this study, we analyzed data from 45 CML patients who had discontinued TKI therapy. Univariate analysis was performed to predict factors that were potentially related to treatment-free remission (TFR) and identify the differences between early relapse and late relapse. Out of the 45 patients, 20 exhibited molecular relapse after a median follow-up of 18 months (range, 1-54 months), and the estimated TFR at 24 months was 40%. The univariate analysis revealed that a high Sokal score and interruptions or dose reductions during TKI treatment were the only baseline factors associated with poor outcomes. Our results indicate that TKI discontinuation could be successfully put into practice in China.
基金：
National Natural Science Foundation of China [81500136, 81670145]
第一作者单位：[1]Huazhong Univ Sci & Technol, Inst Hematol, Union Hosp, Tongji Med Coll, Wuhan 430022, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Shen Na,You Yong,Zhong Zhao-dong,et al.Monitoring and Analysis of Chinese Chronic Myeloid Leukemia Patients Who Have Stopped Tyrosine Kinase Inhibitor Therapy[J].CURRENT MEDICAL SCIENCE.2019,39(2):211-216.doi:10.1007/s11596-019-2021-7.
APA：
Shen, Na,You, Yong,Zhong, Zhao-dong,Meng, Li,Zhou, Jian-feng...&Cheng, Fan-jun.(2019).Monitoring and Analysis of Chinese Chronic Myeloid Leukemia Patients Who Have Stopped Tyrosine Kinase Inhibitor Therapy.CURRENT MEDICAL SCIENCE,39,(2)
MLA：
Shen, Na,et al."Monitoring and Analysis of Chinese Chronic Myeloid Leukemia Patients Who Have Stopped Tyrosine Kinase Inhibitor Therapy".CURRENT MEDICAL SCIENCE 39..2(2019):211-216
