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Expression of autophagy-associated proteins in rat dental irreversible pulpitis

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单位： [1]Tongji Univ, Dept Stomatol, Shanghai Peoples Hosp 10, Sch Med, 301 Yanchang Rd, Shanghai 200072, Peoples R China [2]Nanjing Med Univ, Jiangsu Key Lab Oral Dis, Affiliated Hosp Stomatol, Nanjing 210029, Jiangsu, Peoples R China [3]Huazhong Univ Sci & Technol, Ctr Stomatol, Tongji Hosp, Tongji Med Coll, 1095 Jie Fang Ave, Wuhan 430030, Hubei, Peoples R China

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关键词： autophagy irreversible pulpitis rat dental pulpitis model

摘要：

Autophagy serves an important role in numerous diseases, as well as in infection and inflammation. Irreversible pulpitis (IP) is one of the most common inflammatory endodontic diseases, and autophagy has been reported to regulate IP in vitro. However, the level of autophagy in the IP pathogenic process in vivo remains unknown. The aim of the current study was, thus, to investigate the levels of autophagy-associated proteins in rats with IP in vivo. A rat dental IP model was successfully constructed, and five different time points (0, 1, 3, 5 and 7 days) were investigated. The levels of the autophagy-related 5 (ATG5), ATG7, light chain 3 (LC3) and Beclin-1 proteins exhibited a time-dependent increase in rats with IP, whereas the levels of mammalian target of rapamycin and p62/sequestosome 1 were decreased. In addition, the levels of ATG proteins were specifically increased in odontoblasts and microvascular endothelial cells in pulpitis tissue. Based on these findings, autophagy may serve an important role in IP, and the present study data provide a new insight into the IP pathogenesis and treatment.

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出版当年[2018]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验 4 区肿瘤学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验 4 区肿瘤学

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出版当年[2017]版：

Q3 MEDICINE, RESEARCH & EXPERIMENTAL Q4 ONCOLOGY

最新[2023]版：

Q2 MEDICINE, RESEARCH & EXPERIMENTAL Q2 ONCOLOGY

影响因子： 3.4 最新[2023版] 3 最新五年平均 1.922 出版当年[2017版] 1.912 出版当年五年平均 1.692 出版前一年[2016版] 1.851 出版后一年[2018版]

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第一作者单位： [1]Tongji Univ, Dept Stomatol, Shanghai Peoples Hosp 10, Sch Med, 301 Yanchang Rd, Shanghai 200072, Peoples R China

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