Background. We aimed to conduct a meta-analysis concerning the frequency and risk factors of reduced bone mineral density (BMD) in systemic lupus erythematosus (SLE) with evidence from published studies. Methods. A comprehensive literature search was conducted based on the EMBASE, Web of Science, PubMed, and Cochrane Library databases up to March 5th, 2017. Eligible studies reported any prevalence of reduced BMD in SLE patients. All risk factors with odds ratios or risk ratios associated with reduced BMD were extracted. Results. 71 reports with 33527 SLE patients were included. Low BMD, osteopenia, and osteoporosis at any site were presented, respectively, in 45%, 38%, and 13% of the SLE patients. The prevalence of osteoporosis increased with the advancing of age, while U-shaped associations between age and the prevalence of low BMD and osteopenia were found. Lumbar spine was indicated to have higher prevalence of osteoporosis. Age, disease duration, drugs use, and many other factors were identified as predictors of reduced BMD. Conclusion. Low BMD, osteoporosis, and osteopenia appeared to be prevalent in patients with SLE. Risk factors of reduced BMD were various.
基金：
Major Research Plan of the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [91742204]; international (regional) cooperation and exchange projects (NSFC-DFG) [81761138041]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81470948, 81670633, 81570667]; national key research and development program [2016YFC0906103]; National Key Technology RD ProgramNational Key Technology R&D Program [2013BAI09B06, 2015BAI12B07]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|3 区生物
小类|3 区生物工程与应用微生物4 区医学：研究与实验
最新[2025]版：
大类|4 区医学
小类|4 区生物工程与应用微生物4 区医学：研究与实验
JCR分区：
出版当年[2017]版：
Q2BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q3BIOTECHNOLOGY & APPLIED MICROBIOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Dept Nephrol, Affiliated Tongji Med Coll, 1095 Jie Fang Ave, Wuhan 430030, Hubei, Peoples R China[2]PLA 474 Hosp, Dept Nephrol, Urumqi 830000, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Xia Jumei,Luo Ran,Guo Shuiming,et al.Prevalence and Risk Factors of Reduced Bone Mineral Density in Systemic Lupus Erythematosus Patients: A Meta-Analysis[J].BIOMED RESEARCH INTERNATIONAL.2019,2019:doi:10.1155/2019/3731648.
APA：
Xia, Jumei,Luo, Ran,Guo, Shuiming,Yang, Yi,Ge, Shuwang...&Zeng, Rui.(2019).Prevalence and Risk Factors of Reduced Bone Mineral Density in Systemic Lupus Erythematosus Patients: A Meta-Analysis.BIOMED RESEARCH INTERNATIONAL,2019,
MLA：
Xia, Jumei,et al."Prevalence and Risk Factors of Reduced Bone Mineral Density in Systemic Lupus Erythematosus Patients: A Meta-Analysis".BIOMED RESEARCH INTERNATIONAL 2019.(2019)
