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Involvement of obesity-associated upregulation of chemerin/chemokine-like receptor 1 in oxidative stress and apoptosis in ovaries and granulosa cells

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单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Reprod Med Ctr, 1095 Jiefang Ave, Wuhan, Hubei, Peoples R China [2]Reprod Ctr Maternal & Child Hlth Hosp Guangxi Zhu, 225 Xinyang Rd, Nanning, Guangxi Zhuang, Peoples R China [3]Boai Hosp Zhongshan, Reprod Med Ctr, 6 Chenggui Rd, Zhongshan, Guangdong, Peoples R China [4]Peking Univ, Hosp 3, Pain Med Ctr, 49 North Garden Rd, Beijing, Peoples R China

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关键词： Obesity Chemerin Oxidative stress Apoptosis Granulosa cells

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In this study, we evaluated the expression and function of chemerin and CMKLR1 in the ovaries and granulosa cells of high-fat diet-induced obese (OB) mice. In vivo, chemerin/CMKLR1 system was upregulated in the serum, ovaries, and granulosa cells of OB mice compared with those in control mice. Apoptotic ovarian follicles, oxidative stress, and apoptosis biomarkers were also increased in the ovaries of OB mice. In vitro, mouse granulosa cells (mGCs) were cultured and treated with different concentrations of chemerin to investigate the effects of chemerin on viability, reactive oxygen species (ROS), and apoptosis and on the phosphorylation of AKT, AMP-activated protein kinase alpha (AMPK alpha), and nuclear factor-kappa B p65. Chemerin suppressed mGC viability with or without gonadotrophin and induced ROS accumulation and apoptosis in mGCs. Moreover, AMPKcc and p65 were activated by chemerin, whereas AKT was suppressed. These changes in phosphorylation were blocked with CMKLR1 knockdown. Our findings showed that chemerin contributed to ROS accumulation and apoptotic cell death through three signaling pathways, suggesting that upregulation of chemerin and CMKLR1 may explain the imbalance of oxidative stress and apoptosis in the ovaries of OB mice. (C) 2019 Elsevier Inc. All rights reserved.

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出版当年[2018]版：

大类 | 3 区生物

小类 | 3 区生物物理 4 区生化与分子生物学

最新[2025]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学 4 区生物物理

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出版当年[2017]版：

Q2 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 2.5 最新[2023版] 2.7 最新五年平均 2.559 出版当年[2017版] 2.455 出版当年五年平均 2.466 出版前一年[2016版] 2.705 出版后一年[2018版]

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第一作者单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Reprod Med Ctr, 1095 Jiefang Ave, Wuhan, Hubei, Peoples R China

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