Five new diterpenoid glycosides, dongtingnoids A E (1-5), two new diterpenoid aglycones, dongtingnoids F and G (6 and 7), and two known analogues, cotylenins E and J (8 and 9), belonging to the fusicoccane family, were isolated from the fungus Penicillium sp. DT10, which was derived from wetland soil from Dongting Lake. Their structures and absolute configurations were elucidated based on spectroscopic analyses, acid hydrolysis, ECD calculations, and X-ray crystallography. Dongtingnoid C (3) is the first 16-nor-fusicoccane diterpenoid glycoside reported and is proposed to form by oxidative demethylation. Compounds 1, 4, and 5 showed comparable seed-germination-promoting activities to that previously reported for the growth regulator cotylenin E (8).
基金：
Program for Changjiang Scholars of Ministry of Education of the People's Republic of China [T2016088]; National Natural Science Foundation for Distinguished Young Scholars [81725021]; National Science and Technology Project of China [2018ZX09201001-001-003]; Innovative Research Groups of the National Natural Science Foundation of China [81721005]; Academic Frontier Youth Team of HUST; Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College (HUST)
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Bie Qiong,Chen Chunmei,Yu Muyuan,et al.Dongtingnoids A-G: Fusicoccane Diterpenoids from a Penicillium Species[J].JOURNAL OF NATURAL PRODUCTS.2019,82(1):80-86.doi:10.1021/acs.jnatprod.8b00694.
APA：
Bie, Qiong,Chen, Chunmei,Yu, Muyuan,Guo, Jieru,Wang, Jianping...&Zhang, Yonghui.(2019).Dongtingnoids A-G: Fusicoccane Diterpenoids from a Penicillium Species.JOURNAL OF NATURAL PRODUCTS,82,(1)
MLA：
Bie, Qiong,et al."Dongtingnoids A-G: Fusicoccane Diterpenoids from a Penicillium Species".JOURNAL OF NATURAL PRODUCTS 82..1(2019):80-86
