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Uncovering potential lncRNAs and nearby mRNAs in systemic lupus erythematosus from the Gene Expression Omnibus dataset

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收录情况： ◇ SCIE

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单位： [1]First Hosp Shijiazhuang, Dept Dermatol, Shijiazhuang 050000, Hebei, Peoples R China [2]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Dermatol & Sexol, Wuhan 430030, Hubei, Peoples R China [3]Hebei Med Univ, Dept Med, Affiliated Hosp 3, Shijiazhuang 050000, Hebei, Peoples R China

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关键词： lncRNAs MAPK measles mRNAs protein-protein network systemic lupus erythematosus

摘要：

Aim: The aim of this study was to find potential differentially expressed long noncoding RNAs (lncRNAs) and mRNAs in systemic lupus erythematosus. Materials & methods: Differentially expressed lncRNAs and mRNAs were obtained in the Gene Expression Omnibus dataset. Functional annotation of differentially expressed mRNAs was performed, followed by protein-protein interaction network analysis. Then, the interaction network of lncRNA-nearby targeted mRNA was built. Results: Several interaction pairs of lncRNA-nearby targeted mRNA including NRIR-RSAD2, RP11-153M7.5-TLR2, RP4-758J18.2-CCNL2, RP11-69E11.4-PABPC4 and RP11-496I9.1-IRF7/HRAS/PHRF1 were identified. Measles and MAPK were significantly enriched signaling pathways of differentially expressed mRNAs. Conclusion: Our study identified several differentially expressed lncRNAs and mRNAs. And their interactions may play a crucial role in the process of systemic lupus erythematosus.

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出版当年[2018]版：

大类 | 2 区生物

小类 | 2 区遗传学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区遗传学

JCR分区：

出版当年[2017]版：

Q1 GENETICS & HEREDITY

最新[2023]版：

Q2 GENETICS & HEREDITY

影响因子： 3 最新[2023版] 3.4 最新五年平均 4.979 出版当年[2017版] 4.494 出版当年五年平均 4.541 出版前一年[2016版] 4.404 出版后一年[2018版]

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第一作者单位： [1]First Hosp Shijiazhuang, Dept Dermatol, Shijiazhuang 050000, Hebei, Peoples R China

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