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Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective

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单位: [1]Univ Estado Rio de Janeiro, Fac Ciencias Med, Dept Med Interna, Disciplina Endocrinol, Rio De Janeiro, Brazil [2]Univ Sydney, Inst Endocrinol & Diabet, Sydney, NSW, Australia [3]Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati Childrens Hosp Med Ctr,Div Endocrinol, Cincinnati, OH USA [4]Klinikum Univ Munchen, Med Klin & Poliklin 4, Endocrine Lab, Munich, Germany [5]Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Neuroendocrine Unit, Boston, MA 02115 USA [6]Univ Fed Parana, Dept Pediat, Curitiba, Parana, Brazil [7]Virtus Med Grp, Paediat Endocrinol Genet & Metab, Hong Kong, Peoples R China [8]Univ Hong Kong, Hong Kong, Peoples R China [9]Perth Childrens Hosp, Child & Adolescent Hlth Serv, Dept Endocrinol, Perth, WA, Australia [10]Univ Western Australia, Sch Med, Div Paediat, Perth, WA, Australia [11]Univ Western Australia, Telethon Kids Inst, Ctr Child Hlth Res, Perth, WA, Australia [12]Harvard Med Sch, Boston Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA [13]Univ Southern Calif, Leonard Davis Sch Gerontol, Los Angeles, CA 90007 USA [14]Childrens Natl Hlth Syst, Div Endocrinol, Washington, DC USA [15]CHU St Justine, Endocrine & Diabet Serv, Montreal, PQ, Canada [16]Univ Montreal, Montreal, PQ, Canada [17]Beijing Childrens Hosp, Beijing Diabet Ctr Children & Adolescents, Endocrinol Genet & Metab, Dept Med Genet, Beijing, Peoples R China [18]Tokyo Metropolitan Childrens Med Ctr, Div Endocrinol & Metab, Tokyo, Japan [19]Stanford Univ, Sch Med, Dept Med, Palo Alto, CA 94304 USA [20]VA Palo Alto Hlth Care Syst, Palo Alto, CA USA [21]Univ Auckland, Liggins Inst, Auckland, New Zealand [22]Natl Ctr Child Hlth & Dev, Div Endocrinol & Metab, Tokyo, Japan [23]Univ Sao Paulo, Hosp Clin, Fac Med, Unidade Endocrinol Genet LIM25, Sao Paulo, Brazil [24]Univ Copenhagen, Rigshosp, Dept Growth & Reprod, Copenhagen, Denmark [25]Univ Paris Saclay, Hop Bicetre, AP HP, Serv Endocrinol & Malad Reprod, Paris, France [26]Jehangir Hosp, HCJMRI, Pune, Maharashtra, India [27]HCOM Ohio Univ Athens, Edison Biotechnol Inst, Athens, OH USA [28]HCOM Ohio Univ Athens, Dept Biomed Sci, Athens, OH USA [29]Umea Univ, Inst Clin Sci, Pediat, Umea, Sweden [30]CHU Lisboa, Ctr Hosp Dona Estefania, Unidad Endocrinol Pediat, Area Mulher Crianca & Adolescente, Lisbon, Portugal [31]Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Colleage, Dept Pediat, Wuhan, Peoples R China [32]Univ Minnesota, Dept Pediat, Div Endocrinol, Masonic Childrens Hosp, Minneapolis, MN 55455 USA [33]Massachusetts Gen Hosp, Div Pediat Endocrinol, Boston, MA 02114 USA [34]Harvard Med Sch, Boston, MA 02115 USA [35]Sorbonne Univ, Hop Trousseau, AP HP,INSERM, Explorat Fonct Endocriniennes,Ctr Rech St Antoine, Paris, France [36]Rutgers State Univ, Robert Wood Johnson Med Sch, Child Hlth Inst New Jersey, Dept Pediat, New Brunswick, NJ USA [37]Univ Childrens Hosp, Tubingen, Germany [38]Univ Virginia, Dept Pediat, Charlottesville, VA USA [39]Oregon Hlth & Sci Univ, Portland, OR 97201 USA [40]NYU, Winthrop Hosp, Mineola, NY USA [41]Leiden Univ, Med Ctr, Dept Pediat, Leiden, Netherlands [42]Univ Bonn, Childrens Hosp, Pediat Endocrinol Div, Bonn, Germany
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关键词: Growth Pediatrics Guideline Growth hormone Treatment

摘要:
The Growth Hormone Research Society (GRS) convened a Workshop in March 2019 to evaluate the diagnosis and therapy of short stature in children. Forty-six international experts participated at the invitation of GRS including clinicians, basic scientists, and representatives from regulatory agencies and the pharmaceutical industry. Following plenary presentations addressing the current diagnosis and therapy of short stature in children, breakout groups discussed questions produced in advance by the planning committee and reconvened to share the group reports. A writing team assembled one document that was subsequently discussed and revised by participants. Participants from regulatory agencies and pharmaceutical companies were not part of the writing process. Short stature is the most common reason for referral to the pediatric endocrinologist. History, physical examination, and auxology remain the most important methods for understanding the reasons for the short stature. While some long-standing topics of controversy continue to generate debate, including in whom, and how, to perform and interpret growth hormone stimulation tests, new research areas are changing the clinical landscape, such as the genetics of short stature, selection of patients for genetic testing, and interpretation of genetic tests in the clinical setting. What dose of growth hormone to start, how to adjust the dose, and how to identify and manage a suboptimal response are still topics to debate. Additional areas that are expected to transform the growth field include the development of long-acting growth hormone preparations and other new therapeutics and diagnostics that may increase adult height or aid in the diagnosis of growth hormone deficiency.

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出版当年[2018]版:
大类 | 4 区 医学
小类 | 3 区 儿科 4 区 内分泌学与代谢
最新[2025]版:
大类 | 3 区 医学
小类 | 3 区 儿科 4 区 内分泌学与代谢
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出版当年[2017]版:
Q2 PEDIATRICS Q4 ENDOCRINOLOGY & METABOLISM
最新[2023]版:
Q1 PEDIATRICS Q3 ENDOCRINOLOGY & METABOLISM

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第一作者单位: [1]Univ Estado Rio de Janeiro, Fac Ciencias Med, Dept Med Interna, Disciplina Endocrinol, Rio De Janeiro, Brazil [*1]Pavilhao Reitor Haroldo Lisboa Cunha, Rua Sao Francisco Xavier 524, BR-20550013 Rio De Janeiro, Brazil
通讯作者:
通讯机构: [1]Univ Estado Rio de Janeiro, Fac Ciencias Med, Dept Med Interna, Disciplina Endocrinol, Rio De Janeiro, Brazil [*1]Pavilhao Reitor Haroldo Lisboa Cunha, Rua Sao Francisco Xavier 524, BR-20550013 Rio De Janeiro, Brazil
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