单位：[1]The Center for Biomedical Research,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei, China;华中科技大学同济医学院附属同济医院生物医学研究中心生物医学中心科研平台[2]Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei, China华中科技大学同济医学院附属同济医院内科学系呼吸与危重症医学科[3]China Tobacco Jiangxi Industrial Co., Ltd., Nanchang High Technology Development Valley, Nanchang 330096, Jiangxi, China
Cigarette smoking can increase the risk of many respiratory and chronic systemic diseases. Particularly, cigarette smoke produces toxic particulate matter (PM), which is harmful to the smokers. Although previous studies have demonstrated the toxicity of cigarette smoke PM and its relationship with disease pathogenesis, systematic data for the impact of cigarette smoke PM on physical activity and metabolism in animals are still lacking. In this report, the C57/B6 mice were exposed to cigarette smoke PM in a smoking chamber coupled with the analysis of metabolic changes and physical activity in metabolic cages at indicated time, for a period up to 12-month-old of age. The mice became excited following short period (e.g., 3 months) but listless after long-term cigarette smoke PM exposures (e.g., 9 or 10 months), as manifested by the changes of drink/food intake and daily activities along with increased oxygen consumption and CO2 accumulation. Our data suggest that particulate matter originated from cigarette smoke impairs metabolism and physical activities.
基金：
Integrated Innovative Team for Major Human Disease Programs of Tongji Medical College, Huazhong University of Science and Technology; Innovative Funding for Translational Research from Tongji Hospital
语种：
外文
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PubmedID：
第一作者：
第一作者单位：[1]The Center for Biomedical Research,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei, China;[2]Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei, China
共同第一作者：
通讯作者：
通讯机构：[1]The Center for Biomedical Research,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei, China;[3]China Tobacco Jiangxi Industrial Co., Ltd., Nanchang High Technology Development Valley, Nanchang 330096, Jiangxi, China[*1]The Center for Biomedical Research, Tongji Hospital Research Building, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Tech- nology, Wuhan, Hubei, China.[*2]Technology Center, China Tobacco Jiangxi Industrial Co. Ltd., Nanchang 330096, Jiangxi, China
推荐引用方式(GB/T 7714)：
wu guorao,li yang,zhang lei,et al.The impact of tobacco smoking on physical activity and metabolism in mice[J].INTERNATIONAL JOURNAL OF MOLECULAR EPIDEMIOLOGY AND GENETICS.2019,10(5):67-76.
APA：
wu,guorao,li,yang,zhang,lei,zhang,huilan,su,jiakun...&wang,cong-yi.(2019).The impact of tobacco smoking on physical activity and metabolism in mice.INTERNATIONAL JOURNAL OF MOLECULAR EPIDEMIOLOGY AND GENETICS,10,(5)
MLA：
wu,guorao,et al."The impact of tobacco smoking on physical activity and metabolism in mice".INTERNATIONAL JOURNAL OF MOLECULAR EPIDEMIOLOGY AND GENETICS 10..5(2019):67-76
