Outcomes of allogeneic haematopoietic stem cell transplantation for patients with severe aplastic anaemia using the porcine antilymphocyte globulin-containing conditioning regimen
单位：[1]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Hematol,1095 Jie Fang Ave,Wuhan 430030,Hubei,Peoples R China内科学系血液内科华中科技大学同济医学院附属同济医院[2]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Inst Organ Transplantat,Wuhan 430030,Peoples R China器官移植研究所华中科技大学同济医学院附属同济医院器官移植
Antithymocyte globulin (ATG) is widely used for allogeneic haematopoietic stem cell transplantation (allo-HSCT) in severe aplastic anaemia (SAA). Only rabbit-ATG (r-ATG) and porcine-antilymphocyte globulin (p-ALG) are available in China, but the p-ALG-containing conditioning regimen for allo-HSCT in SAA has seldom been reported. In this study, we retrospectively evaluated the outcomes of 41 SAA patients receiving allo-HSCT with a p-ALG-containing conditioning regimen in our transplantation centre. All patients engrafted, and no death during conditioning was observed. The actuarial 3-year overall survival (OS) rates were 95.1 +/- 3.4%. The actuarial 3-year disease-free survival (DFS) rates were 85.0 +/- 5.7%. Acute graft-versus-host disease (aGVHD)predicted inferior OS (p < 0.05). The interval from diagnosis to transplantation for more than 100 days predicted an inferior DFS rate (p < 0.05) and a higher graft rejection/poor graft function (GR/PGF) rate (p < 0.01). In conclusion, the p-ALG-containing regimen showed satisfactory effects and safety in allo-HSCT for SAA patients. P-ALG could be a potential alternative preparation for r-ATG in SAA allo-HSCT.
基金：
National Natural Science Foundation of China [81570163, 81873446, 81873427, 81700174, 81400147]
第一作者单位：[1]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Hematol,1095 Jie Fang Ave,Wuhan 430030,Hubei,Peoples R China
通讯作者：
通讯机构：[1]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Hematol,1095 Jie Fang Ave,Wuhan 430030,Hubei,Peoples R China[2]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Inst Organ Transplantat,Wuhan 430030,Peoples R China
推荐引用方式(GB/T 7714)：
Li Lin,Li Yun,Lin Li,et al.Outcomes of allogeneic haematopoietic stem cell transplantation for patients with severe aplastic anaemia using the porcine antilymphocyte globulin-containing conditioning regimen[J].ANNALS OF HEMATOLOGY.2020,99(8):1863-1871.doi:10.1007/s00277-020-04111-5.
APA：
Li, Lin,Li, Yun,Lin, Li,Yin, Jin,Xu, Jinhuan...&Zhang, Yicheng.(2020).Outcomes of allogeneic haematopoietic stem cell transplantation for patients with severe aplastic anaemia using the porcine antilymphocyte globulin-containing conditioning regimen.ANNALS OF HEMATOLOGY,99,(8)
MLA：
Li, Lin,et al."Outcomes of allogeneic haematopoietic stem cell transplantation for patients with severe aplastic anaemia using the porcine antilymphocyte globulin-containing conditioning regimen".ANNALS OF HEMATOLOGY 99..8(2020):1863-1871
