Cilia are ubiquitous in mammalian cells. The formation and assembly of cilia depend on the normal functioning of the ciliary transport system. In recent years, various proteins involved in the intracellular transport of the cilium have attracted attention, as many diseases are caused by disorders in cilia formation. Intraflagellar transport 20 (IFT20) is a subunit of IFT complex B, which contains approximately 20 protein particles. Studies have shown that defects in IFT20 are associated with numerous system-related diseases, such as those of the urinary system, cardiovascular system, skeletal system, nervous system, immune system, reproductive system, and respiratory system. This review summarizes current research on IFT20. We describe studies related to the role of IFT20 in cilia formation and discuss new targets for treating diseases associated with ciliary dysplasia.
基金：
Health and Family Planning Commission of Hubei Province [WJ2019M133]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Div Gastroenterol, Jiefang Rd 1095, Wuhan, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhou Ming-hui,Lin Yi,Zhang Zhen-gang.Intraflagellar transport 20: New target for the treatment of ciliopathies[J].BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH.2020,1867(7):doi:10.1016/j.bbamcr.2019.118641.
APA：
Zhou, Ming-hui,Lin, Yi&Zhang, Zhen-gang.(2020).Intraflagellar transport 20: New target for the treatment of ciliopathies.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH,1867,(7)
MLA：
Zhou, Ming-hui,et al."Intraflagellar transport 20: New target for the treatment of ciliopathies".BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1867..7(2020)
