CXC chemokine family has been related to atherogenesis for long. However, the relationship between CXCL14 and atherogenesis is still unclear. This study preliminarily detected CXCL14 expression at foam cells in atherosclerosis specimens by immunohistochemistry. In vitro foam cells were derived from THP-1 after phorbol-12-myristate-13-acetate (PMA) and oxidized low-density lipoprotein (ox-LDL) stimulation. Immunoblotting and qPCR convinced CXCL14 expression variation during foam cell formation. We further demonstrated that ox-LDL regulated CXCL14 expression by AP-1. AP-1 could bind to CXCL14 promoter and up-regulate CXCL14 mRNA expression. Besides, CXCL14 promoted THP-1 migration, macrophage lipid phagocytosis, and smooth muscle cell migration as well as proliferation mainly via the ERK1/2 pathway. Additionally, a CXCL14 peptide-induced immune therapy showed efficacy in ApoE(-/-) mouse model. In conclusion, our study demonstrated that CXCL14 is highly up-regulated during foam cell formation and promotes atherogenesis in various ways. CXCL14 may be a potent therapeutic target for atherosclerosis.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区医学
小类|4 区心脏和心血管系统4 区医学：研究与实验
最新[2025]版：
大类|4 区医学
小类|4 区心脏和心血管系统4 区医学：研究与实验
JCR分区：
出版当年[2018]版：
Q2CARDIAC & CARDIOVASCULAR SYSTEMSQ3MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q2CARDIAC & CARDIOVASCULAR SYSTEMSQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者单位：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Inst Pathol,Wuhan 430030,Peoples R China[2]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Pathol, Wuhan 430030, Peoples R China
通讯作者：
通讯机构：[1]Huazhong Univ Sci & Technol,Tongji Hosp,Tongji Med Coll,Inst Pathol,Wuhan 430030,Peoples R China[2]Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Pathol, Wuhan 430030, Peoples R China
推荐引用方式(GB/T 7714)：
Tong Weilin,Duan Yaqi,Yang Rumeng,et al.Foam Cell-Derived CXCL14 Muti-Functionally Promotes Atherogenesis and Is a Potent Therapeutic Target in Atherosclerosis[J].JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH.2020,13(2):215-224.doi:10.1007/s12265-019-09915-z.
APA：
Tong, Weilin,Duan, Yaqi,Yang, Rumeng,Wang, Ying,Peng, Changqing...&Wang, Guoping.(2020).Foam Cell-Derived CXCL14 Muti-Functionally Promotes Atherogenesis and Is a Potent Therapeutic Target in Atherosclerosis.JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH,13,(2)
MLA：
Tong, Weilin,et al."Foam Cell-Derived CXCL14 Muti-Functionally Promotes Atherogenesis and Is a Potent Therapeutic Target in Atherosclerosis".JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH 13..2(2020):215-224
