Cigarette smoke exposure stimulates prostatic fibrosis and the potential protective functions of green tea epigallocatechin-3-gallate via regulating Hedgehog pathway
Cigarettes consumption is popular all over the world. In the meantime, green tea is widely accepted for their health benefits. Epigallocatechin-3-gallate (EGCG) is the most abundant catechin in green tea. This study aimed to investigate the effects of cigarette smoke (CS) exposure on human prostate cells and rat prostate, as well as the potential protective functions of EGCG. The results suggested that chronic CS exposure stimulated prostatic epithelial-mesenchymal transition (EMT), collagen deposition and fibrosis. Down-regulation of the Hedgehog (HH) signaling pathway helped to ameliorate CS-induced prostatic deficits. Meanwhile, EGCG could exhibit strong anti-fibrosis effects on prostate. Its underlying mechanisms were related to modulate EMT and decrease the activity of HH signal pathway.
基金：
State Natural Sciences Fund of China [81703594, 81603177]
第一作者单位：[1]Jianghan Univ, Affiliated Hosp, Hosp Wuhan 6, Gerontol Res Ctr, Wuhan, Peoples R China[2]Jianghan Univ, Med Coll, Wuhan, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Chen Jinglou,Lei Yongfang,Liu Min.Cigarette smoke exposure stimulates prostatic fibrosis and the potential protective functions of green tea epigallocatechin-3-gallate via regulating Hedgehog pathway[J].JOURNAL OF FUNCTIONAL FOODS.2020,66:doi:10.1016/j.jff.2020.103795.
APA：
Chen, Jinglou,Lei, Yongfang&Liu, Min.(2020).Cigarette smoke exposure stimulates prostatic fibrosis and the potential protective functions of green tea epigallocatechin-3-gallate via regulating Hedgehog pathway.JOURNAL OF FUNCTIONAL FOODS,66,
MLA：
Chen, Jinglou,et al."Cigarette smoke exposure stimulates prostatic fibrosis and the potential protective functions of green tea epigallocatechin-3-gallate via regulating Hedgehog pathway".JOURNAL OF FUNCTIONAL FOODS 66.(2020)
