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MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis

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收录情况： ◇ SCIE

作者：
sun,chaoyang[1] * ; li,xi[1] ; guo,ensong[1] ; li,na[1,2] ; zhou,bo[1,3] ; lu,hao[1,4] ; huang,jia[1] ; xia,meng[1,4] ; shan,wanying[1] ; wang,beibei[1] ; li,kezhen[1] ; weng,danhui[1] ; xu,xiaoyan[1] ; gao,qinglei[1] ; wang,shixuan[1] ; hu,junbo[1,5] ; lu,yiling[6] ; mills,gordon b.[6] ; chen,gang[1] ;
单位： [1]Department of Gynecology and Obstetrics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 Hubei,PR China [2]Cancer Genetics Laboratory of Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia [3]Department of Gynecology Oncology, Zhongnan Hospital of Wuhan University, Wuhan 430071 Hubei, PR China [4]Department of Gynecology and Obstetrics, The Central Hospital of Wuhan, Wuhan 430030 Hubei, PR China [5]Department of Gastrointestinal Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 Hubei,PR China [6]Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
出处：
DOI： 10.1038/s41388-019-1090-1
ISSN：

摘要：
Ovarian cancer selective metastasizes to the omentum contributing to the poor prognosis associated with ovarian cancer. However, the mechanism underlining this propensity and therapeutic approaches to counter this process has not been fully elucidated. Here, we show that MCP-1 produced by omental adipocytes binding to its cognate receptor CCR-2 on ovarian cancer cells facilitates migration and omental metastasis by activating the PI3K/AKT/mTOR pathway and its downstream effectors HIF-1 alpha and VEGF-A in cell lines, xenografts, and transgenic murine models. MCP-1 antibody significantly decreased tumor burden and increased survival of mice in vivo. Interestingly, metformin decreased omental metastasis at least partially by inhibiting MCP-1 secretion from adipocytes independent of direct effects on cancer cells. Together this suggests a novel target of MCP-1/CCR-2 axis that could benefit ovarian cancer patients.

基金：
National Key R&D Program of China [2016YFC1303100]; National Basic Research Program of China (973 Program)National Basic Research Program of China [2015CB553903]; Nature and Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81272859, 81572569, 81402163, 81402164, 81501530, 81671394, 81370469]; International S&T Cooperation Program of China [2013DFA31400]; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [P50CA217685]; Ovarian Cancer Research Foundation

基金编号： 2016YFC1303100 2015CB553903 81272859 81572569 81402163 81402164 81501530 81671394 81370469 2013DFA31400 P50CA217685

语种：
外文
被引次数：
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PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类 | 1 区 医学
小类 | 2 区 生化与分子生物学 2 区 细胞生物学 2 区 遗传学 2 区 肿瘤学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 生化与分子生物学 1 区 遗传学 2 区 细胞生物学 2 区 肿瘤学
JCR分区：
出版当年[2018]版：
Q1 ONCOLOGY Q1 GENETICS & HEREDITY Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CELL BIOLOGY
最新[2023]版：
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CELL BIOLOGY Q1 GENETICS & HEREDITY Q1 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者单位： [1]Department of Gynecology and Obstetrics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 Hubei,PR China
通讯作者：
推荐引用方式(GB/T 7714)：
sun chaoyang,li xi,guo ensong,et al.MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis[J].ONCOGENE.2020,39(8):1681-1695.doi:10.1038/s41388-019-1090-1.
APA：
sun,chaoyang,li,xi,guo,ensong,li,na,zhou,bo...&chen,gang.(2020).MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis.ONCOGENE,39,(8)
MLA：
sun,chaoyang,et al."MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis".ONCOGENE 39..8(2020):1681-1695

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