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Digoxin is associated with worse outcomes in patients with heart failure with reduced ejection fraction

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收录情况： ◇ SCIE

作者：
Zhou, Jingmin[1] * ; Cao, Juan[1,2,13] ; Jin, Xuejuan[1] ; Zhou, Jun[1] ; Chen, Zhenyue[3,42] ; Xu, Dingli[4] ; Yang, Xinchun[5] ; Dong, Wei[6] ; Li, Liwen[7,30] ; Fan, Yuyuan[1,2,13] ; Chen, Li[2,13] ; Zhong, Qiaoqing[8,10] ; Fu, Micheal[9] ; Hu, Kai[1] ; Ge, Junbo[1] ; Lu, Yingmin[11] ; Zhang, Guohui[12] ; Li Chen[13] ; Gu, Huimin[14] ; Wei, Meng[15] ; Chen, Lianglong[16] ; Wang, Jun[17] ; Yang, Zhenyu[18] ; Jin, Huigen[19] ; Li, Xianliang[20] ; Qiao, Zengyong[21] ; Yang, Yingjun[22] ; Zhao, Yulan[23] ; Jia, Ru[24] ; Hong, Bin[25] ; Yuan, Fang[26] ; Wang, Jufei[27] ; Ma, Jin[28] ; Xu, Yu[29] ; Wahafu, Mahmud[31] ; Yu, Qin[32] ; Wang, Changqian[33] ; Ruan, Changwu[34] ; Fu, Honggang[35] ; Liu, Xuebo[36] ; Xu, Xin[37] ; Chen, Shaoping[38] ; Liu, Qiliang[39] ; Shi, Bei[40] ; Xu, Jiahong[41] ;
单位： [1]Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Dept Cardiol, 180 Fenglin Rd, Shanghai 200032, Peoples R China [2]North Sichuan Med Coll, Affiliated Hosp, Dept Cardiol, Nanchang, Sichuan, Peoples R China [3]Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Cardiol, Sch Med, Shanghai, Peoples R China [4]Southern Med Univ, Nanfang Hosp, Dept Cardiol, Guangzhou, Peoples R China [5]Capital Med Univ, Heart Ctr, Beijing Chaoyang Hosp, Beijing, Peoples R China [6]Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing, Peoples R China [7]Guangdong Acad Med Sci, Guangdong Gen Hosp, Guangdong Cardiovasc Inst, Dept Cardiol, Guangzhou, Peoples R China [8]First Peoples Hosp Chenzhou, Dept Cardiol, Chenzhou, Peoples R China [9]Univ Gothenburg, Ostra Hosp, Sect Cardiol, Sahlgrenska Univ Hosp,Dept Med, Gothenburg, Sweden [10]Chenzhou 1 Peoples Hosp, Chenzhou, Peoples R China [11]Shanghai Jiao Tong Univ, Xin Hua Hosp, Sch Med, Chongming Branch, Shanghai, Peoples R China [12]Zhenjiang First Peoples Hosp, Zhenjiang, Jiangsu, Peoples R China [13]North Sichuan Med Coll, Affiliated Hosp, Nanchong, Peoples R China [14]First Peoples Hosp Kunshan, Kunshan, Peoples R China [15]Shanghai Sixth Peoples Hosp, Shanghai, Peoples R China [16]Fujian Med Univ, Union Hosp, Fuzhou, Peoples R China [17]Jingan Dist Cent Hosp Shanghai, Shanghai, Peoples R China [18]Wuxi Peoples Hosp, Wuxi, Jiangsu, Peoples R China [19]Putuo Peoples Hosp Shanghai, Shanghai, Peoples R China [20]Zhangjiagang Hosp Tradit Chinese Med, Zhangjiagang, Peoples R China [21]Shanghai Fengxian Dist Cent Hosp, Shanghai, Peoples R China [22]Jiashan First Peoples Hosp, Jiashan, Peoples R China [23]Zhenzhou Univ, Affiliated Hosp 2, Zhengzhou, Peoples R China [24]4 Hosp 1946 Jinan Shandong, Jinan, Peoples R China [25]Shanghai Qingpu Dist Cent Hosp, Shanghai, Peoples R China [26]Shanghai Chest Hosp, Shanghai, Peoples R China [27]Fenghua Hosp, Fenghua, Peoples R China [28]Tongji Univ, Yangpu Hosp, Shanghai, Peoples R China [29]Henan Prov Peoples Hosp, Zhengzhou, Peoples R China [30]Guangdong Gen Hosp, Guangzhou, Peoples R China [31]Second Peoples Hosp Kashgar Prefecture, Kashi, Xinjiang, Peoples R China [32]Dalian Univ, Zhongshan Hosp, Dalian, Peoples R China [33]Shanghai Ninth Peoples Hosp, Shanghai, Peoples R China [34]Shanghai Eighth Peoples Hosp, Shanghai, Peoples R China [35]Fuyuan Peoples Hosp, Qujing, Peoples R China [36]Tongji Univ, Shanghai East Hosp, Shanghai, Peoples R China [37]Wuxi 2 Peoples Hosp, Wuxi, Jiangsu, Peoples R China [38]Changhai Hosp Shanghai, Shanghai, Peoples R China [39]Putuo Dist Ctr Hosp, Shanghai, Peoples R China [40]Hosp Zunyi Med Coll, Zunyi, Guizhou, Peoples R China [41]Tongji Univ, Tongji Hosp, Wuhan, Peoples R China [42]Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Shanghai, Peoples R China
出处：
DOI： 10.1002/ehf2.12539
ISSN：

关键词： Digoxin Heart failure Atrial fibrillation Prognosis

摘要：
Aims The aim of this study was to investigate the impact of digoxin use on the outcomes of patients with heart failure with reduced ejection fraction (HFrEF) and its possible interaction with atrial fibrillation or use of currently guideline-recommended treatments in the real world in China. Methods and results Patients hospitalized with HFrEF from 45 hospitals participating in the China National Heart Failure Registration Study (CN-HF) were enrolled to assess the all-cause mortality, HF mortality, all-cause re-hospitalization, and HF re-hospitalization associated with digoxin use. Eight hundred eighty-two eligible HFrEF patients in the CN-HF registry were included: 372 patients with digoxin and 510 patients without digoxin. Among them, 794 (90.0%) patients were followed up for the endpoint events, with a median follow-up of 28.6 months. Kaplan-Meier survival analysis showed that the all-cause mortality (P < 0.001) and all-cause re-hospitalization (P = 0.020) were significantly higher in digoxin group than non-digoxin group, while HF mortality (P = 0.232) and HF re-hospitalization (P = 0.098) were similar between the two groups. The adjusted Cox proportional-hazards regression analysis demonstrated that digoxin use remained as an independent risk factor for increased all-cause mortality [hazard ratio (HR) 1.76; 95% confidence interval (CI) 1.27-2.44; P = 0.001] and all-cause re-hospitalization (HR 1.27; 95% CI 1.03-1.57; P = 0.029) in HFrEF patients and the predictive value of digoxin for all-cause mortality irrespective of rhythm or in combination with other guideline-recommended therapies. Conclusions Digoxin use is independently associated with increased risk of all-cause mortality and all-cause re-hospitalization in HFrEF patients.

基金：
National Science & Technology Pillar Program, 12th 5-year plan of China [2011BAI11B10]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类 | 3 区 医学
小类 | 3 区 心脏和心血管系统
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 心脏和心血管系统
JCR分区：
出版当年[2018]版：
Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
最新[2023]版：
Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者单位： [1]Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Dept Cardiol, 180 Fenglin Rd, Shanghai 200032, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhou Jingmin,Cao Juan,Jin Xuejuan,et al.Digoxin is associated with worse outcomes in patients with heart failure with reduced ejection fraction[J].ESC HEART FAILURE.2020,7(1):139-147.doi:10.1002/ehf2.12539.
APA：
Zhou, Jingmin,Cao, Juan,Jin, Xuejuan,Zhou, Jun,Chen, Zhenyue...&Xu, Jiahong.(2020).Digoxin is associated with worse outcomes in patients with heart failure with reduced ejection fraction.ESC HEART FAILURE,7,(1)
MLA：
Zhou, Jingmin,et al."Digoxin is associated with worse outcomes in patients with heart failure with reduced ejection fraction".ESC HEART FAILURE 7..1(2020):139-147

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