The lysine-proline-valine tripeptide (KPV) can transport into colorectal cancer (CRC) cells via oligopeptide transporter 1 (PepT1) selectively. Here, we successfully designed a fluorescent probe for PepT1 receptor-targeted CRC imaging. This probe consisted of the CuInS2/ZnS (CIS/ZnS) quantum dots (QDs) conjugated with KPV (QD-PAAO-KPV), exhibiting excellent near-infrared emission characteristics. The in vitro and in vivo results showed that the QD-PAAO-KPV was specifically and efficiently internalized in the PepT1-overexpressing colorectal Caco-2 tumor. In addition, it demonstrated that the probe possessed good biological activities. Thus, this study revealed that the probe QD-PAAO-KPV presented desirable targeting ability, showing promising prospects in CRC detection.
语种：
外文
被引次数：
WOS：
中科院(CAS)分区：
出版当年[2019]版：
大类|4 区化学
小类|4 区物理化学4 区物理：原子、分子和化学物理
最新[2025]版：
大类|3 区化学
小类|3 区物理：原子、分子和化学物理4 区物理化学
JCR分区：
出版当年[2018]版：
Q3CHEMISTRY, PHYSICALQ3PHYSICS, ATOMIC, MOLECULAR & CHEMICAL
第一作者单位：[1]China Pharmaceut Univ, Sch Engn, Dept Biomed Engn, State Key Lab Nat Med, Nanjing 210009, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Niu Qi,Yu Xiyuan,Yuan Qinling,et al.Quantum dots based near-infrared fluorescent probe for the detection of PepT1 expression in colorectal cancer[J].CHEMICAL PHYSICS LETTERS.2020,739:doi:10.1016/j.cplett.2019.136977.
APA：
Niu, Qi,Yu, Xiyuan,Yuan, Qinling,Hu, Weijie,Yu, Dongsheng&Zhang, Qi.(2020).Quantum dots based near-infrared fluorescent probe for the detection of PepT1 expression in colorectal cancer.CHEMICAL PHYSICS LETTERS,739,
MLA：
Niu, Qi,et al."Quantum dots based near-infrared fluorescent probe for the detection of PepT1 expression in colorectal cancer".CHEMICAL PHYSICS LETTERS 739.(2020)
