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Identification of gene expression profiles and immune cell infiltration signatures between low and high tumor mutation burden groups in bladder cancer

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单位： [1]Shandong Univ, Dept Urol, Qilu Hosp, 107 Wenhuaxi Rd, Jinan 250012, Shandong, Peoples R China [2]Huazhong Univ Sci & Technol, Tongji Hosp, Div Gastroenterol, Wuhan, Hubei, Peoples R China

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关键词： tumor mutation burden bladder cancer gene expression profile immune cell TCGA database

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Bladder cancer is one of the most commonly diagnosed tumors and is results from the accumulation of somatic mutations in the DNA. Tumor mutation burden (TMB) has been associated with cancer immunotherapeutic response. In this study, we attempted to explore the correlation between TMB and cancer prognosis. Identify the different expressed genes and immune cell infiltration signatures between low and high TMB group. Mutation data, gene expression profiles and clinical data were downloaded from The Cancer Genome Atlas (TCGA) database. Patients were divided into high and low TMB groups, allowing differentially expressed genes (DEGs) to be identified. Functional enrichment and protein-protein interaction (PPI) network analysis were used to identify the functions of the DEGs. And immune cell infiltration signatures were evaluated by CIBERSORT algorithm. These results shown that high TMB was significantly associated with prognosis. We obtained a list of TMB related genes which may influence the infiltrations of immune cells. We also found a higher proportion of CD8 T cells, CD4 T cells and NK cells in the high TMB group. Our data suggest that higher TMB tends to promote the infiltrations of T cells and NK cells and patients with higher TMB may achieve a more favorable prognosis in bladder cancer.

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出版当年[2019]版：

大类 | 3 区医学

小类 | 3 区医学：内科

最新[2025]版：

大类 | 3 区医学

小类 | 3 区医学：内科

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出版当年[2018]版：

Q2 MEDICINE, GENERAL & INTERNAL

最新[2023]版：

Q1 MEDICINE, GENERAL & INTERNAL

影响因子： 3.2 最新[2023版] 3.4 最新五年平均 2.333 出版当年[2018版] 2.636 出版当年五年平均 2.284 出版前一年[2017版] 2.523 出版后一年[2019版]

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第一作者单位： [1]Shandong Univ, Dept Urol, Qilu Hosp, 107 Wenhuaxi Rd, Jinan 250012, Shandong, Peoples R China

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