单位：[1]Institute of Liver Disease,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China华中科技大学同济医学院附属同济医院肝脏胃肠病研究所[2]Department of Hepatic Surgery Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China华中科技大学同济医学院附属同济医院外科学系肝脏外科
This study aimed to identify functional single nucleotide polymorphisms in the cyclooxygenase-2 gene promoter and evaluate their effects on the risk of primary hepatocellular carcinoma (HCC) with hepatitis B virus (HBV) infection.We conducted a population-based,casecontrol study enrolling 630 Han Chinese people in Hubei province.Subjects included primary HCC patients with HBV infection (n=210),chronic hepatitis B cases (n=210) and healthy Han Chinese (n=210).-1195G/A polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCRRFLP) and sequencing analysis.We found-1195A allele carriers had a higher risk of HCC with HBV infection (OR,0.72;95% CI,0.548-0.946).The-1195A allele might be used as a marker in screening individuals at high risk of HCC with HBV infection.
基金：
Acknowledgements The study was supported by the National Natural Science Foundation of China (Grant No. 30872237) and the Special Funds for State Key Development Program for Basic Research of China (973 Program) (No. 2007CB512903). We are indebted to Ping Xiong (Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, China) for his assistance in recruiting subjects.
语种：
外文
第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Liu L.-F,Zhang J.-L,Chen Q,et al.Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC:A case-control study in Han Chinese people[J].FRONTIERS OF MEDICINE IN CHINA.2010,4(1):90-95.doi:10.1007/s11684-010-0021-x.
APA：
Liu, L.-F,Zhang, J.-L,Chen, Q,Chang, Y&Lin, J.-S.(2010).Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC:A case-control study in Han Chinese people.FRONTIERS OF MEDICINE IN CHINA,4,(1)
MLA：
Liu, L.-F,et al."Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC:A case-control study in Han Chinese people".FRONTIERS OF MEDICINE IN CHINA 4..1(2010):90-95
