Axonal damage in myelin oligodendrocyte glycoprotein peptide-induced experimental autoimmune encephalomyelitis in a C57BL/6 mouse model may be not secondary to inflammatory demyelination
The present study established a chronic experimental autoimmune encephalomyelitis model in C57BL/6 mice induced by myelin oligodendrocyte glycoprotein peptides and complete Freund's adjuvant. Onset latency was 12 days, with an incidence rate of 100%. Neuropathological characteristics included perivascular inflammatory cell infiltration, demyelination, neuronal degeneration, and axonal damage within cerebral and myelic white matter. Electron microscopy revealed swollen mitochondria, complete organ disappearance, and fused or broken myelin sheath structure, which were accompanied by myelin sheath reconstruction. Moreover, axonal damage was not consistent with demyelination distribution, and severity of axonal damage did not correlate with demyelination. Results suggested that axonal damage in an experimental autoimmune encephalomyelitis model is not secondary to inflammatory demyelination.
基金：
Natural Science Foundation of Ministry of Science and Technology of China [30230140]; Merck Serono (China)
第一作者单位：[1]Huazhong Univ Sci & Technol,Tongji Med Coll,Tongji Hosp,Dept Neurol,Wuhan 430030,Hubei Province,Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Gao Boting,Chen Juan,Wang Qiong,et al.Axonal damage in myelin oligodendrocyte glycoprotein peptide-induced experimental autoimmune encephalomyelitis in a C57BL/6 mouse model may be not secondary to inflammatory demyelination[J].NEURAL REGENERATION RESEARCH.2011,6(29):2267-2272.doi:10.3969/j.issn.1673-5374.2011.29.005.
APA：
Gao, Boting,Chen, Juan,Wang, Qiong,Wang, Wei&Tang, Zhouping.(2011).Axonal damage in myelin oligodendrocyte glycoprotein peptide-induced experimental autoimmune encephalomyelitis in a C57BL/6 mouse model may be not secondary to inflammatory demyelination.NEURAL REGENERATION RESEARCH,6,(29)
MLA：
Gao, Boting,et al."Axonal damage in myelin oligodendrocyte glycoprotein peptide-induced experimental autoimmune encephalomyelitis in a C57BL/6 mouse model may be not secondary to inflammatory demyelination".NEURAL REGENERATION RESEARCH 6..29(2011):2267-2272
