During placental development, oxygen environment is not only critical for trophoblasts migration and invasion, but also fundamental for appropriate placental perfusion. Cysteine-rich 61 (Cyr61, CCN1) was expressed in the extravillous trophoblasts (EVTs) and decreased in preeclampsia. Its regulatory properties in human first-trimester extravillous trophoblast cell line (TEV-1 cells) upon a low oxygen tension were investigated. The present study examined functional changes involved in adaptation to hypoxia of the TEV-1 cells, using cobalt chloride (CoCl2) as hypoxic mimic. It was found that hypoxia inhibited growth of TEV-1 cells and induced the increase of cell apoptosis (P<0.05). The Cyr61 expression in human EVTs was transcriptionally induced by CoCl2. Inappropriate EVTs apoptosis has been implicated in the failure of trophoblasts to fully invade and modify the uterine environment and Cyr61 down-regulation, potentially leading to preeclampsia.
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Hosp, Dept Obstet & Gynecol, Tongji Med Coll, Wuhan 430030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Chen Xi,Liu Yanyan,Xu Xiaoyan,et al.Decreased Cyr61 under Hypoxia Induces Extravillous Trophoblasts Apoptosis and Preeclampsia[J].JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES.2011,31(2):235-240.doi:10.1007/s11596-011-0259-9.
APA：
Chen, Xi,Liu, Yanyan,Xu, Xiaoyan&Chen, Hanping.(2011).Decreased Cyr61 under Hypoxia Induces Extravillous Trophoblasts Apoptosis and Preeclampsia.JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES,31,(2)
MLA：
Chen, Xi,et al."Decreased Cyr61 under Hypoxia Induces Extravillous Trophoblasts Apoptosis and Preeclampsia".JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES 31..2(2011):235-240
