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Valsartan Inhibits Angiotensin II-induced Proliferation of Vascular Smooth Muscle Cells via Regulating the Expression of Mitofusin 2

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单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Cardiol, Wuhan 430030, Peoples R China [2]Cent Hosp Wuhan, Dept Cardiol, Wuhan 430014, Peoples R China

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关键词： valsartan angiotensin II vascular smooth muscle cells proliferation mitofusin 2

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Angiotensin II (ANG II) plays an important role in the pathogenesis of atherosclerosis by inducing proliferation of vascular smooth muscle cells (VSMCs). In our study, we observed the effects of valsartan on proliferation of cultured VSMCs treated with or without ANG II by cell counting and methyl thiazolyl tetrazolium (MTT) assay, and detected the expression of mitofusin 2 (Mfn2), a newly discovered cell proliferation inhibitor and a related cell proliferation signaling pathway protein by Western blotting. ANG II at a concentration of 10(-6) mol/L significantly stimulated VSMCs proliferation, down-regulated the expression of Mfn2 and up-regulated the expression of Raf and ERK1/2. Valsartan inhibited such effects of ANG II at concentrations of 10(-5) and 10(-6) mol/L, but not at 10(-7) mol/L. Valsartan had no significant effect on the proliferation of untreated VSMCs. These results suggest that valsartan inhibits ANG II-induced proliferation of VSMCs in vitro via Mfn2-Ras-Raf-ERK/MAPK signaling pathway.

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出版当年[2011]版：

大类 | 4 区医学

小类 | 4 区生化与分子生物学

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出版当年[2010]版：

Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

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影响因子： 0 最新[2023版] 0 最新五年平均 0.405 出版当年[2010版] 0 出版当年五年平均 0.311 出版前一年[2009版] 0.385 出版后一年[2011版]

第一作者：

第一作者单位： [1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Cardiol, Wuhan 430030, Peoples R China [2]Cent Hosp Wuhan, Dept Cardiol, Wuhan 430014, Peoples R China

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