Non-alcoholic fatty liver disease (NAFLD) is hepatic manifestation of a metabolic syndrome and includes a spectrum of hepatic steatosis, steatohepatitis, and fibrosis. Interleukin-17 (IL-17) has been reported to play a critical role in inflammatory progression of some liver diseases. The present study was designed to investigate the role of IL-17 on high fat diet-induced NAFLD in C57BL/6 mice. IL-17 blockade with anti-IL-17mAb significantly improved liver function, attenuated hepatic lipid accumulation, suppressed Kuffer cells activation, and decreased proinflammatory cytokines levels, which were associated with inhibition of NF-kappa B signaling cascades activation. Our data suggested that IL-17 was related to disease progression in NAFLD mouse model and blocking IL-17 may be a promising novel therapeutic approach for patients with NAFLD.
基金：
National Natural Science Foundation of China [30971248]
第一作者单位：[1]Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Endocrinol, Wuhan 430030, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Xu Renfan,Tao Anyu,Zhang Shasha,et al.Neutralization of interleukin-17 attenuates high fat diet-induced non-alcoholic fatty liver disease in mice[J].ACTA BIOCHIMICA ET BIOPHYSICA SINICA.2013,45(9):726-733.doi:10.1093/abbs/gmt065.
APA：
Xu, Renfan,Tao, Anyu,Zhang, Shasha&Zhang, Muxun.(2013).Neutralization of interleukin-17 attenuates high fat diet-induced non-alcoholic fatty liver disease in mice.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,45,(9)
MLA：
Xu, Renfan,et al."Neutralization of interleukin-17 attenuates high fat diet-induced non-alcoholic fatty liver disease in mice".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 45..9(2013):726-733
