单位:[1]national clinical guidelines centre,royal college of physicians,london nw1 4le,uk[2]royal surrey county hospital nhs foundation trust,guildford,uk[3]department of oncology and metabolism,university of sheffield,sheffield,uk[4]华中科技大学同济医学院附属同济医院肿瘤中心华中科技大学同济医学院附属同济医院肿瘤科