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The prognostic impact of tumor location in non-muscle-invasive bladder cancer patients undergoing transurethral resection: insights from a cohort study utilizing chinese multicenter and SEER registries

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资源类型：
Pubmed体系：
作者：
Liu Lilong[1] * ; Li Kaiwen[2] * ; Wang Shao-Gang[1] * ; Wang Jianli[3] ; Yao Zhipeng[1] ; Xie Yu[4] ; Ji Zhigang[5] ; Chen Zhiwen[6] ; Hu Hailong[7] ; Chen Haige[8] ; Hu Junyi[1] ; Hou Yaxin[1] ; Liu Zhenghao[1] ; Li Yang[1] ; Ding Yuhong[1] ; Kuang Yingchun[1] ; Xun Yang[1] ; Hu Jia[1] ; Zhang Jiaqiao[1] ; Li Heng[1] ; Chong Tie[9] ; Bi Jianbin[10] ; Wang Zhiping[11] ; Wang Yinhuai[12] ; Zhang Peng[13] ; Wei Qiang[13] ; Chen Zhaohui[14] ; Li Lei[15] ; Huang Jian[2,*1] ; Liu Zheng[1,*2] ; Chen Ke[1,*2] ;
单位： [1]Department of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China. [2]Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen (Zhongshan) University, Guangzhou, Guangdong, China. [3]Department of Urology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. [4]Department of Urology, the Affiliated Cancer Hospital of Xiangya School of Medicine of Central South University, Hunan Cancer Hospital, Changsha, Hunan, China. [5]Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. [6]Department of Urology, The First Affiliated Hospital of the Third Military Medical University, Chongqing, China. [7]Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China. [8]Department of Urology, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. [9]Department of Urology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi, China. [10]Department of Urology, The First Hospital of China Medical University, Shenyang, Liaoning, China. [11]Clinical Center of Gansu Province for Urological Diseases, Lanzhou University Second Hospital, Lanzhou City, Gansu, China. [12]Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. [13]Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. [14]Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. [15]Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi, China.
出处：
DOI： 10.1097/JS9.0000000000001675
ISSN：

关键词： Non-muscle invasive bladder cancer Tumor location Transurethral resection of bladder tumors Bladder dome Partial cystectomy

摘要：
Most bladder cancers are non-muscle invasive bladder cancer (NMIBC), and transurethral resection of bladder tumors (TURBT) is the standard treatment. However, postoperative recurrence remains a significant challenge, and the influence of bladder tumor location on prognosis is still unclear. This study aims to investigate how tumor location affects the prognosis of NMIBC patients undergoing TURBT and to identify the optimal surgical approach.A multicenter study was conducted, which included Chinese NMIBC data from 15 hospitals (1996-2019) and data from 17 registries of the Surveillance, Epidemiology, and End Results database (SEER) (2000-2020). Patients initially diagnosed with NMIBC and undergoing TURBT or partial cystectomy were analyzed, with cases lost to follow-up or with missing data excluded. The study investigated the overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) among patients with different tumor locations. Kaplan-Meier, Cox regression, and propensity score matching methods were employed to explore the association between tumor location and prognosis. Stratified populations were analyzed to minimize bias.This study included 118,477 NMIBC patients and highlighted tumor location as a crucial factor impacting post-TURBT prognosis. Both anterior wall and dome tumors independently predicted adverse outcomes in two cohorts. For anterior wall tumors, the Chinese cohort showed hazard ratios (HR) for OS of 4.35 (P < 0.0001); RFS of 2.21 (P < 0.0001); SEER cohort OS HR of 1.10 (P = 0.0001); DSS HR of 1.13 (P = 0.0183). Dome tumors displayed similar trends (Chinese NMIBC cohort OS HR of 7.91 (P < 0.0001); RFS HR of 2.12 (P < 0.0001); SEER OS HR of 1.05 (P = 0.0087); DSS HR of 1.14 (P = 0.0006)). Partial cystectomy significantly improved the survival of dome tumor patients compared to standard TURBT treatment (P < 0.01).This study reveals the significant impact of tumor location in NMIBC patients on the outcomes of TURBT treatment, with tumors in the anterior wall and bladder dome showing poor post-TURBT prognosis. Compared to TURBT treatment, partial cystectomy improves the prognosis for bladder dome tumors. This study provides guidance for personalized treatment and prognosis management for NMIBC patients.Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.

语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 2 区 医学
小类 | 2 区 外科
最新[2025]版：
大类 | 2 区 医学
小类 | 2 区 外科
第一作者：
第一作者单位： [1]Department of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China. [2]Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen (Zhongshan) University, Guangzhou, Guangdong, China. [*1]Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen (Zhongshan) University, Guangzhou, Guangdong, China [*2]Department of Urology,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China
推荐引用方式(GB/T 7714)：
Liu Lilong,Li Kaiwen,Wang Shao-Gang,et al.The prognostic impact of tumor location in non-muscle-invasive bladder cancer patients undergoing transurethral resection: insights from a cohort study utilizing chinese multicenter and SEER registries[J].International Journal Of Surgery (London, England).2024,doi:10.1097/JS9.0000000000001675.
APA：
Liu Lilong,Li Kaiwen,Wang Shao-Gang,Wang Jianli,Yao Zhipeng...&Chen Ke.(2024).The prognostic impact of tumor location in non-muscle-invasive bladder cancer patients undergoing transurethral resection: insights from a cohort study utilizing chinese multicenter and SEER registries.International Journal Of Surgery (London, England),,
MLA：
Liu Lilong,et al."The prognostic impact of tumor location in non-muscle-invasive bladder cancer patients undergoing transurethral resection: insights from a cohort study utilizing chinese multicenter and SEER registries".International Journal Of Surgery (London, England) .(2024)

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